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Mouse Imaging Centre (MICe)
Canadian Mouse Mutant Repository (CMMR)
Centre for Modelling Human Disease (CMHD)

Mouse Imaging Centre (MICe)


J. Ellegood, B.A. Babineau, R.M. Henkelman, J.P. Lerch, J.N. Crawley. Neuroanatomical Analysis of the BTBR Mouse Model of Autism using Magnetic Resonance Imaging and Diffusion Tensor Imaging. NeuroImage 70:288-301, 2013.
DOI 10.1016/j.neuroimage.2012.12.029 PMID 23275046

D.K. Manning, M. Sergeev, R.G. van Heesbeen, M.D. Wong, J.H. Oh, R.M. Henkelman, I. Drummond, J.V. Shah, D.R. Beier. Loss of the Ciliary Kinase Nek8 Causes Left-Right Asymmetry Defects. Journal of the American Society of Nephrology 24(1):100-112, 2013.
DOI 10.1681/ASN.2012050490 PMID 23274954

P. Parasoglou, C. A. Berrios-Otero, B. J. Nieman, D. H. Turnbull. High-resolution MRI of Early Stage Mouse Embryos. NMR in Biomedicine 26(2):224-231, 2013.
DOI 10.1002/nbm.2843 PMID 22915475

A.L. Wheeler, J.P. Lerch, M.M. Chakravarty, M. Friedel, J.G. Sled, P.J. Fletcher, S.A. Josselyn, P.W. Frankland. Adolescent cocaine exposure causes enduring macroscale changes in mouse brain structure. Journal of Neuroscience 33(5):1797-1803, 2013.
PMID 23365219

A.L. Wheeler, A.H. Wang, C.M. Teixeira, X. Xiong, J.P. Lerch, A.R. McIntosh, J. Parkinson, P.W. Frankland. Identification of a functional network for long-term fear memory in mice. PLoS Computational Biology 9(1):e1002853, 2013.
DOI 10.1371/journal.pcbi.1002853 PMID 23300432


S.A. Bainbridge, A. Minhas, K.J. Whiteley, D. Qu, J.G. Sled, J.C.P. Kingdom, S.L. Adamson. Effects of Reduced Gcm1 Expression of Trophoblast Morphology, Feto-placental Vascularity and Pregnancy Outcomes in Mice. Hypertension 59(3):732-739, 2012.
DOI 10.1161/HYPERTENSIONAHA.111.183939 PMID 22275534

C.A. Berrios-Otero, B.J. Nieman, P. Parasoglou, D.H. Turnbull. In Utero Phenotyping of Mouse Embryonic Vasculature with MRI. Magnetic Resonance in Medicine 67(1):251-257, 2012.
DOI 10.1002/mrm.22991 PMID 21590728

L.S. Cahill, C.L. Laliberté, J. Ellegood, S. Spring, J.A. Gleave, M.C. van Eede, J.P. Lerch, R.M. Henkelman. Preparation of Fixed Mouse Brains for MRI. NeuroImage 60(2):933-939, 2012.
DOI 10.1016/j.neuroimage.2012.01.100 PMID 22305951

M.M. Chakravarty, D. Felsky, M. Tampakeras, J.P. Lerch, B. Mulsant, J. Kennedy, A. Voineskos. DISC1 and striatal volume: a potential risk phenotype for mental illness. Frontiers in Neuropsychiatric Imaging and Stimulation 3:57, 2012.
DOI 10.3389/fpsyt.2012.00057 PMID 22723785.

B.P. Chugh, J. Bishop, Y-Q. Zhou, J. Wu, R.M. Henkelman, J.G. Sled. A Robust Method for 3D Arterial Spin Labeling in Mice. Magnetic Resonance in Medicine 68(1):98-106, 2012.
DOI 10.1002/mrm.23209 PMID 22102489

J. Ellegood, R.M. Henkelman, J.P. Lerch. Magnetic Resonance Imaging as a Tool for the Study of Mouse Models of Autism. Autism S1:008, 2012.
DOI 10.4172/2165-7890.S1-008

J. Ellegood, R.M. Henkelman, J.P. Lerch. Neuroanatomical Assessment of the Integrin β3 Mouse Model related to Autism and Serotonin System using High Resolution MRI. Frontiers of Psychiatry Translational Imaging Genetics 3:37, 2012.
DOI 10.3389/psyt.2012.00037 PMID 22557981

L. M. Gazdzinski, K. Cormier, F. G. Lu, J. P. Lerch, C. S. Wong, B. J. Nieman. Radiation-induced Alterations in Mouse Brain Development Characterized by MRI. International Journal of Radiation Oncology Biology Physics 84(5):e631-e638, 2012.
DOI 10.1016/j.ijrobp.2012.06.053 PMID 22975609

J.A. Gleave, M.D. Wong, J. Dazai, M. Altaf, R.M. Henkelman, J.P. Lerch, B.J. Nieman. Neuroanatomical Phentoyping of the Mouse Brain with Three-dimensional Autofluorescence Imaging. Physiological Genomics 44(15):778-785, 2012.
DOI 10.1161/physiolgenomics.00055.2012 PMID 22718750

J.P. Lerch, L. Gazdzinski, J. Germann, J.G. Sled, R.M. Henkelman, B.J. Nieman. Wanted Dead or Alive? The Tradeoff between In-Vivo versus Ex-vivo MR Brain Imaging in the Mouse. Frontiers in Neuroinformatics 6:6, 2012.
DOI 10.3389/fninf.2012.00006 PMID22470335

A. Mansouri, W. Min, C.J. Cole, S.A. Josselyn, J.T. Henderson, M. van Eede, R.M. Henkelman, C. Ackerley, E. Grunebaum, C.M. Roifman. Cerebellar Abnormalities in Purine Nucleoside Phosphorylase Deficient Mice. Neurobiology of Disease 47(2):201-209, 2012.
DOI 10.1016/j.nbd.2012.04.001 PMID 22521465

B.J. Nieman, M.C. Blank, B.B. Roman, R.M. Henkelman, K.J. Millen. If the Skull Fits: Magnetic Resonance Imaging and Microcomputed Tomography for Combined Analysis of Brain and Skull Phenotypes in the Mouse. Physiological Genomics44:992-1002, 2012.
DOI 10.1152/physiogenomics.00093.2012 PMID 22947655

M.Y. Rennie, J. Detmar, K.J. Whiteley, A. Jurisicova, S.L. Adamson, J.G. Sled. Expansion of the Fetoplacental Vasculature in Late Gestation is Strain Dependant in Mice. American Journal of Physiology-Heart and Circulatory Physiology 302(6):H1261-1273, 2012.
DOI 10.1152/ajpheart.00776.2011 PMID 22268107

G. Winocur, M. Henkelman, M. Wojtowicz, H. Zhang, M. Binns, I. Tannock. The Effects of Chemotherapy on Cognitive Function in a Mouse Model: A Prospective Study. Clinical Cancer Research 18(11):3112-3121, 2012.
DOI 10.1158/10788-0432.CCR-12-0060 PMID 22467680

J. Yang, H. Noyan-Ashraf, A. Meissner, J. Voiglaender-Bolz, J.T. Kroetsch, W. Foltz, D. Jaffray, A. Kapoor, A. Momen, S.P. Hexmier, H. Zhang, M. van Eede, M. Henkelman, S.G. Matthews, D. Lidington, M. Husain, S-S. Bolz. Proximal Cerebral Arteries Develop Myogenic Responsiveness in Heart Failure Via TNFα-dependent Activation of S1P Signaling. Circulation 126(2):196-206, 2012.
DOI 10.1161/CIRCULATIONAHA.111.039644 PMID 22668972

M.D. Wong, A.E. Dorr, J.R. Walls, J.P. Lerch, R.M. Henkelman. A Novel 3D Mouse Embryo Atlas Based on Micro-CT. Development 139(17):3248-3256, 2012.
DOI 10.1242/dev.082016 PMID 22872090


W. Huang, Z. Zhou, S. Asrar, M. Henkelman, W. Xie, Z. Jia. p21-Activated Kinases 1 and 3 control Brain Size through Coordinating Neuronal Complexity and Synaptic Properties. Molecular and Cellular Biology 31(3):388-403, 2011.
DOI 10.1128/MCB.00969-10 PMID 21115725

J.J. Kim, P.S. Gill, L. Rotin, M. van Eede, M. Henkelman, C-C. Hui, N.D. Rosenblum. Suppressor of Fused Controls Mid-Hindbrain Patterning and Cerebellar Morphogenesis Via GL13 Repressor. Journal of Neuroscience 31(5):1825-1836, 2011.
PMID 21289193

J.P. Lerch, J.G. Sled, R.M. Henkelman. MRI Phenotyping of Genetically Altered Mice. Methods in Molecular Biology 711:349-361, 2011.
PMID 21279611

J.P. Lerch, A.P. Yiu, A. Martinez-Canabal, T. Pekar, V.D. Bohbot, P.W. Frankland, R.M. Henkelman, S.A. Josselyn, J.G. Sled. Maze Training in Mice Induces MRI Detectable Brain Shape Changes Specific to the Type of Learning. NeuroImage 54(3):2086-2095, 2011.
DOI 10.1016/j.neuroimaging.2010.09.068 PMID 20932918

E.E. Mueller, A. Momen, S. Massé, Y-Q. Zhou, J. Liu, P.H. Backx, R.M. Henkelman, K. Nanthakumar, D.J. Stewart, M. Husain. Electrical Remodeling Precedes Heart Failure in an Endothelin-1-induced Model of Cardiomyopathy. Cardiovascular Research 89(3):623-633, 2011.
DOI 10.1093/cvr/cvq351 PMID 21062919

M.Y. Rennie, J. Detmar, K. Whiteley, J. Yang, A. Jurisicova, S.L. Adamson, J.G. Sled. Vessel Tortuousity and Reduced Vascularization in the Fetoplacental Arterial Tree after Maternal Exposure to Polycyclic Aromatic Hydrocarbons. American Journal of Physiology-Heart and Circulatory Physiology 300(2):H675-H684, 2011.
DOI 10.1152/ajpheart.00510.2010 PMID 21148768.

J.K. Takeuchi, X. Lou, J.M. Alexander, H. Sugizaki, P. Delgado-Olguin, A.K. Holloway, A.D. Mori, J.N. Wylie, C. Munson, Y. Zhu, Y.Q. Zhou, R.F. Yeh, R.M. Henkelman, R.P. Harvey, D. Metzger, P. Chambon, D.Y. Stainier, K.S. Pollard, I.C. Scott, B.G. Bruneau. Chromatin Remodeling Complex Dosage Modulates Transcription Factor Function in Heart Development. Nature Communications 2:187, 2011.
DOI 10.1038/ncomms1187(2011) PMID 2130451


L. Coultas, E. Nieuwenhuis, G.A. Anderson, R.M. Henkelman, C-C. Hui, J. Rossant. Hedgehog Regulates Blood Vascular Development through VEGF Dependent and Independent Mechanisms. Blood 116(4):653-660, 2010.
DOI 10.1182/blood-2009-12-256644 PMID 20339091

J. Dazai, S. Spring, L.S. Cahill, R.M. Henkelman. Multiple-Mouse Neuroanatomical Magnetic Resonance Imaging (Video Article). Journal of Visualized Experiments (JoVE), 2010. DOI 10.3791/2497

J. Ellegood, L.K. Pacey, D.R. Hampson, J.P. Lerch, R.M. Henkelman. Anatomical Phenotyping in a Mouse Model of Fragile X Syndrome with Magnetic Resonance Imaging. NeuroImage. Epub ahead of print, 19 March 2010.
DOI 10.1016/j.neuromage.2010.03.038 PMID 20304074

F. Fouladkou, C. Lu, C. Jiang, L. Zhou, Y. She, J.R. Walls, H. Kawabe, N. Brose, R.M. Henkelman, A. Huang, B.G. Bruneau, D. Rotin. The Ubiguitin Ligase NEDD4-1 is Required for Heart Development and is a Suppressor of Thrombospondin-1. Journal of Biological Chemistry 285(9):6770-6780, 2010.
DOI 10.1074/jbc.M109.082347 PMID 20026598

R.M. Henkelman. Systems Biology through Mouse Imaging Centers: Experience and New Directions. Annual Review of Biomedical Engineering 12:143-166, 2010.
DOI 10.1146/annurev-bioeng-070909-105343 PMID 20415591

B.J. Nieman, J.Y. Shyu, J.J. Rodriguez, A.D. Garcia, A.L. Joyner, D.H. Turnbull. In Vivo MRI of Neural Cell Migration Dynamics in the Mouse Brain. NeuroImage 50(2):456-464, 2010.
DOI 10.1016/j.neuroimage.2009.12.107 PMID 20053381

B.J. Nieman, D.H. Turnbull. Ultrasound and Magnetic Resonance Microimaging of Mouse Development. Methods in Enzymology 476:379-400, 2010.
PMID 20691877

R.E. Norman, J.G. Flanagan, S.M.K. Rausch, I.A. Sigal, I. Tertinegg, A. Eilaghi, S. Portnoy, J.G. Sled, C.R. Ethier. Dimensional of the Human Sclera: Thickness Measurement and Regional changes with Axial Length. Experimental Eye Research 90(2):277-284, 2010.
DOI 10.1016/j.exer.2009.11.001 PMID 19900442

M. Sauvé, K. Ban, M.A. Momem, Y-Q, Zhou, R.M. Henkelman, M. Husain, D.J. Drucker. Genetic Deletion or Pharmacological Inhibition of Dipeptidyl Peptidase-4 Improves Cardiovascular Outcomes following Myocardial Infarction in Mice. Diabetes 59(4):1063-1073, 2010.
DOI 10.2337/db09-0955 PMID 20097729

S. Spring, J.P. Lerch, M.K. Wetzel, A.C. Evans, R.M. Henkelman. Cerebral Asymmetries in 12-week- old C57Bl/6J Mice Measured by Magnetic Resonance Imaging. NeuroImage 50(2):409-415, 2010.
DOI 10.1016/j.neuorimage.2009.12.043 PMID 20026229

T.J. Sproule, J.G. Sled, J. Wentzell, B. Wang, R.M. Henkelman, D.C. Roopenian, R.W. Burgess. A Mouse Model of Heritable Cerebrovascular Disease. PLoS One 5(12):e15327, 2010.
DOI 10.1371/journal.pone.0015327 PMID 21217823

M. Toporsian, M. Jerkic, Y-Q. Zhou, M.G. Kabir, L.X. Yu, B.A. McIntyre, A. Davis, Y.J. Wang, D.J. Stewart, J. Belik, M. Husain, M. Henkelman, M. Letarte. Spontaneous Adult-onset Pulmonary Arterial Hypertension Attributable to Increase Endothelial Oxidative Stress in a Murine Model of Hereditary Hemorrhagic Telangiectasia. Artrosclerosis, Thrombosis and Vascular Biology 30(3):509-517, 2010.
DOI 10.1161/ATVBAHA.109.200121 PMID 20042709

K. Xu, E. Nieuwenhuis, B. Cohen, W. Wang, A.J. Canty, J. Danska, L. Coultas, J. Rossant, M.Y. Wu, T.D. Piscione, A. Nagy, A. Gossler, G.G. Hicks, C-C. Hui, R.M. Henkelman, L.X. Yu, J.G. Sled, T. Gridley, S.E. Egan. Lunatic Fringe-mediated Notch Signaling is Required for Lung Alveogenesis. American Journal of Physiology: Lung Cellular and Molecular Physiology 298(1):L45-L56, 2010.
DOI 10.1152/ajplung.90550.2008 PMID 19897741

J. Yang, L.X. Yu, M.Y. Rennie, J.G. Sled, R.M. Henkelman. Comparative Structural and Hemodynamic Analysis of Vascular Trees. American Journal of Physiology-Heart and Circulatory Physiology 298:H1249-H1259, 2010.
DOI 10.1152/ajpheart.00363.2009 PMID 20081111

T. Yu, Z. Li, Z. Jia, S.J. Clapcote, C. Liu, S. Li, S. Asrar, A. Pao, R. Chen, N. Fan, S. Carattini-Rivera, A.R. Bechard, S. Spring, R.M. Henkelman, G. Stocia, S. Matsui, N.J. Nowak, J.C. Roder, C. Chen, A. Bradley, Y.E. Yu. A Mouse Model of Down Syndrome Trisomic for All Human Chromosome 21 Syntenic Regions. Human Molecular Genetics 19(14):2780-2791, 2010.
PMID 20442137

M. Zamyadi, L. Baghdadi, J. Lerch, S. Bhattacharya, J. Schneider, R.M. Henkelman, J.G. Sled. Mouse Embryonic Phenotyping by Morphometric Analysis of MR Imaging. Physiological Genomics. Epub ahead of print, 3 August 2010.
DOI 10.1152/physiolgenomics.00091.2010 PMID 20682847

X. Zhang, J.E. Schneider, S. Portnoy, S. Bhattacharya, R.M. Henkelman. Comparative SNR for High Throughput Mouse Embryo MR Microscopy. Magnetic Resonance in Medicine 63(6):1703-1707, 2010.
DOI 10.1002/mrm.22352 PMID 20512875

Y-Q. Zhou, S-N. Zhu, F.S. Foster, M.I. Cybulsky, R.M. Henkelman. Aortic Regurgitation Dramatically Alters the Distribution of Atherosclerotic Lesions and Enhances Atherogenesis in Mice. Atherosclerosis, Thrombosis and Vascular Biology 30:1181-1188, 2010.
DOI 10.1161/ATVBAHA.100.204198 PMID 2029968


J. Belik, M. Jerkic, B.A. McIntyre, J. Pan, J. Leen, L. Yu, R.M. Henkelman, M. Toporsian, M. Letarte. Age-Dependent Endothelial Nitric Oxide Synthase Uncoupling in Pulmonary Arteries of Endoglin Heterozygous Mice. American Journal of Physiology: Lung Cellular and Molecular Physiology 297(6):L1170-L1178, 2009.
DOI 10.1152/ajplung.00168.2009 PMID 19820034

B.P. Chugh, J.P. Lerch, L.X. Yu, M. Pienkowski, R.V. Harrison, R.M. Henkelman, J.G. Sled. Measurement of Cerebral Blood Volume in Mouse Brain Regions Using Micro-Computed Tomography. NeuroImage 47:1312-1318, 2009.
DOI 10.1016/j.neuroimage.2009.03.083 PMID 19362597

S.J. Clapcote, S. Duffy, G. Xie, G. Kirshenbaum, A.R. Bechard, V.R., Schack, J. Petersen, L. Sinai, B.J. Saab, J.P. Lerch, B.A. Minassian, C.A. Ackerley, J.G. Sled, M.A. Cortez, J.T. Henderson, B. Vilsen, J.C. Roder. Mutation 1810N in the {alpha} 3 Isoform of Na+,K+-ATPase Causes Impairments in the Sodium Pump and Hyperexcitability in the CNS. Proceedings of the National Academy of Science 106:14085-14090, 2009.
DOI 10.1073/pnas.0904817106 PMID 19666602

S.K. Ho, N. Kovacevic, R.M. Henkelman, A. Boyd, T. Pawson, J.T. Henderson. EphB2 and EphA4 Receptors Regulate Formation of the Principle Inter-hemispheric Tracts of the Mammalian Forebrain. Neuroscience 160(4):784-795, 2009.
DOI 10.1016/j.neuroscience.2009.03.013 PMID 19289155

O. Kaidanovich-Beilin, T.V. Lipina, K. Takao, M. van Eede, S. Hattori, C. Laliberté, M. Khan, K. Okamoto, J.W. Chambers, P.J. Fletcher, K. MacAulay, B.W. Doble, M. Henkelman, T. Miyakawa, J. Roder, J.R. Woodgett. Abnormalities in Brain Structure and Behavior in GSK-3 Mutant Mice. Molecular Brain 2:35, 2009.
DOI 10.1186/1756-6606-2-35 PMID 19925672

S.C. Kale, X.J. Chen, R.M. Henkelman. Trading Off SNR and Resolution in MRI Images. NMR in Biomedicine 22:488-494, 2009.
DOI 10.1002/nbm.1359 PMID 19123210

K. Koshiba-Takeuchi, A.D. Mori, B.L. Kaynak, J. Cebra-Thomas, T. Sukonnik, R.O. Georges, S. Latham, L. Beck, R.M. Henkelman, B.L. Black, E.N. Olson, J. Wade, J.K. Takeuchi, M. Nemer, S.F. Gilbert, B.G. Bruneau. Reptilian Heart Development and the Molecular Basis of Cardiac Chamber Evolution. Nature 461, 3 September 2009.
DOI 10.38/nature.08324 PMID 19727199

M. Marxen, J.G. Sled, R.M. Henkelman. Volume Ordering for Analysis and Modeling of Vascular Systems. Annals of Biomedical Engineering 37(3):542-551, 2009.
DOI 10.1007/s10439-008-9623-8 PMID 19107598

R.E. Mercer, E.M. Kwolek, J.M. Bischof, M. van Eede, R.M. Henkelman, R. Wevrick. Regionally Reduced Brain Volume, Altered Serotonin Neurochemistry, and Abnormal Behavior in Mice Null for the Circadian Rhythm Output Gene Magel2. American Journal of Medical Genetics B Neuropsychiatry Genetics 150B:1085-1099, 2009.
DOI 10.1002/ajmg.b.30934 PMID 19199291

M.H. Noyan-Ashraf, M.A. Momen, K. Ban, A.M. Sadi, Y.Q. Zhou, A.M. Riazi, L.L. Baggio, R.M. Henkelman, M. Husain, D.J. Drucker. The GLP-1R Agonist Liraglutide Activates Cytoprotective Pathways and Improves Outcomes Following Experimental Myocardial Infarction in Mice. Diabetes 58(4):975-983, 2009.
DOI 10.2337/db08-1193 PMID 19161200

S. Portnoy, S.C. Kale, A. Feintuch, C. Tardif, G.B. Pike, R.M. Henkelman. Information Content of SNR/Resolution Tradeoffs in Three Dimensional Magnetic Resonance Imaging. Medical Physics 36(4):1442-1451, 2009.
DOI 10.1118/1.3098124 PMID 19472651

J.G. Sled, S. Spring, M. van Eede, J.P. Lerch, S. Ullal, B. Sakic. The Time Course and Nature of Brain Atrophy in the MRL Model of CNS Lupus. Arthritis and Rheumatism 60(6):1764-1774, 2009.
DOI 10.002/art.24523 PMID 19479832

S. Stapleton, H. Goodman, Y-Q. Zhou, E. Cherin, R.M. Henkelman, P.N. Burns, F.S. Foster. Acoustic and Kinetic Behaviour of Definity in Mice Exposed to High Frequency Ultrasound. Ultrasound in Medicine and Biology 35(2):296-307, 2009.
DOI 10.1016/j.ultrasmedbio.2008.08.010 PMID 18950930


J. Detmar, M.Y. Rennie, K.J. Whiteley, D. Qu, Y. Taniuchi, X., Shang, R.F. Casper, S.L Adamson, J.G. Sled, A. Jurisicova. Fetal Growth Restriction Triggered by Polycyclic Aromatic Hydrocarbons is Associated with Altered Placental Vasculature and AhR-dependent Changes in Cell Death. American Journal of Physiology Endocrinology and Metabolism 295:E519-E530, 2008.
DOI 10.1152/ajpendo.90436.2008

A.E. Dorr, J.P. Lerch, S. Spring, N. Kabani, R.M. Henkelman. High Resolution Three Dimensional Brain Atlas using an Average Magnetic Resonance Imaging of 40 Adult C57BL/6J Mice. NeuroImage. 42(1):60-69, 2008.
DOI 10.1016/j.neuroimage.2008.03.037

S. Grabherr, M. Dominietto, L. Yu, V. Djonov, B. Müller, S. Friess. Angiofil: a novel radio-contrast agent for post-mortem micro-angiography. In: Developments in X-Ray Tomography VI. Edited by Stuart R. Stock. Proceedings of SPIE 7078: 70781O, 2008.
DOI 10.1117/12.792077

S.C. Kale, J.P. Lerch, R.M. Henkelman, X.J. Chen. Optimization of the SNR-Resolution Tradeoff for Registration in Magnetic Resonance Images. Human Brain Mapping 29:1147-1158, 2008.
DOI 10.1002/hbm.20453

J.C. Lau, J.P. Lerch, J.G. Sled, R.M. Henkelman, A.C. Evans, B.J. Bedell. Longitudinal Neuroanatomical Changes Determined by Deformation-Based Morphometry in Mouse Models of Alzheimer’s Disease. NeuroImage 42:19-67, 2008.
DOI 10.1016/j.neuroimage.2008.04.252

J.P. Lerch, J.B. Carroll, S. Spring, L.N. Bertram, C. Schwab, M.R. Hayden, R.M. Henkelman. Automated Deformation Analysis in the YAC128 Huntington Disease Mouse Model. NeuroImage 39(1):32-39, 2008.
DOI 10.1016/j.neuroimage.2007.08.033

J.P. Lerch, J.B. Carrol, A. Dorr, S. Spring, M. Hayden, J.G. Sled, R.M. Henkelman. Cortical Thickness Measured from MRI in the YAC128 Mouse Model of Huntington’s Disease. NeuroImage. 41(2):243-251, 2008 (Cover Illustration).
DOI 10.1016/j.neuroimage.2008.02.019

T.V. Lipina, S.J. Clapcote, K. Millar, Y. Gondo, R.M. Henkelman, D.J. Porteous, J.C. Roder. Impaired function of phosphodiesterase 4B mutated disc 1 mice leads to development of pronounced depression-like behavior with mild expression of schizophrenia-like phenotype. In: Behavioral Models of Stress Research. Edited by A.V. Kalueff and J.L. LaPorte. New York: Nova Biomedical Books, 2008.

J.R. Walls, L. Coultas, J. Rossant, R.M. Henkelman. Three-Dimensional Analysis of Vascular Development in the Mouse Embryo. PLoS-ONE 3(8):e2853, 2008.
DOI 10.1371/journal.pone.0002853.

K.N. Watt, J. Bishop, B.J. Nieman, R.M. Henkelman, X.J. Chen. Oxygen-enhanced MR Imaging of Mice Lungs. Magnetic Resonance in Medicine 59(6):1412-1421, 2008.
DOI 10.1002/mrm.21517

M.K. Wetzel, S. Naska, C.L. Laliberte, V.V. Rymar, M. Fujitani, J.A. Biernaskie, C.J. Cole, J.P. Lerch, S. Spring, S-H. Wang, P.W. Frankland, R.M. Henkelman, S.A. Josselyn, A.F. Sadikot, F.D. Miller, D.R. Kaplan. p73 Regulates Neurodegeneration and Phospho-Tau Accumulation During Aging and Alzheimer’s Disease. Neuron 59:708-721, 2008.
DOI 10.1016/j.neuron.2008.07.021

Y. Zhu, A.O. Gramolini, M.A. Walsh, Y-Q. Zhou, C. Slorach, M. Freidberg, J.K. Takeuchi, H. Sun, R.M. Henkelman, P.H. Backx, A.N. Redington, D.H. MacLennan, B.G. Bruneau. Tbx5-Dependent Pathway Regulating Diastolic Function in Congenital Heart Disease. PNAS 105(14):5519-5524, 2008.
DOI 10.1073/pnas.0801779105 PMID 18378906


M. Allard, D. Côté, L. Davidson, J. Dazai, R.M. Henkelman. Bioluminescence Tomography in Mice: Impact of Anatomy on the Forward Problem. J. Biol. Optics 12:034018, 2007 (Cover Illustration).
DOI 10.1117/1.2745298

E. Chan, N. Kovacevic, S. Ho, R.M. Henkelman, J.T. Henderson. Development of a High Resolution Three-Dimensional Surgical Atlas of the Murine Head for Strains 129S1/SvImJ and C57B1/6J Mice using Magnetic Resonance Imaging and Micro-Computed Tomography. Neuroscience 144:604-615, 2007.
DOI 10.1016/j.neuroscience.2006.08.080

S.J. Clapcote, T.V. Lipina, J.K. Millar, S. Mackie, S. Christie, F. Ogawa, J.P. Lerch, K. Trimble, M. Uchiyama, Y. Sakuraba, H. Kaneda, T. Shiroishi, M.D. Houslay, R.M. Henkelman, J.G. Sled, Y. Gondo, D.J. Porteous. Behavioral Phenotypes of Disc1 Missense Mutations in Mice. Neuron 54:387-402, 2007.
DOI 10.1016/j.neuron.2007.04.015

A. Dorr, J.G. Sled, N. Kabani. Three Dimensional Cerebral Vasculature of the CBA Mouse Brain: A Magnetic Resonance Imaging and Micro Computed Tomography Study. NeuroImage 35:1409-1423, 2007.
DOI 10.1016/j.neuroimage.2006.12.040

A. Feintuch, P. Ruengsakulrach, A. Lin, J. Zhang, Y-Q. Zhou, J. Bishop, L. Davidson, D. Courtmann, S. Foster, M. Henkelman, C.R. Ethier. Hemodynamics in the Mouse Aortic Arch as Assessed by MRI, Ultrasound and Numerical Modeling. American Journal of Physiology Heart and Circulatory Physiology 292:H884-H892, 2007.
DOI 10.1152/ajpheart.00796.2006

A. Feintuch, Y. Zhou, J. Bishop, L. Davidson, B.G. Bruneau, R.M. Henkelman. 4D Cardiac MRI in the Mouse. NMR in Biomedicine 20:360-365, 2007.
DOI 10.1002/nbm.1164

B.J. Nieman, J. Bishop, J. Dazai, N.A. Bock, J.P. Lerch, A. Feintuch, X.J. Chen, J.G. Sled, R.M. Henkelman. NMR Technology for Biological Studies in Mice. NMR in Biomedicine 20:291-303, 2007.
DOI 10.1002/nbm.1142

B.J. Nieman, J.P. Lerch, N.A. Bock, X.J. Chen, J.G. Sled, R.M. Henkelman. Mouse Behavioral Mutants Have Neuroimaging Abnormalities. Human Brain Mapping 28(6):567-575, 2007.
DOI 10.1002/hbm.20408

M.Y. Rennie, K.J. Whiteley, S. Kulandavelu, S.L. Adamson, J.G. Sled. 3D Visualisation and Quantification by Microcomputed Tomography of Last Gestational Changes in the Arterial and Venous Feto-placental Vasculature of the Mouse. Placenta 28:833-840, 2007.
DOI 10.1016/j.placenta.2006.12.005

S. Spring, J. Lerch, R.M. Henkelman. Sexual Dimorphism Revealed in the Structure of the Mouse Brain using Three-Dimensional Magnetic Resonance Imaging. NeuroImage 35:1424-1433, 2007.
DOI 10.1016/j.neuroscience.2007.02.023

J.R. Walls, J.G. Sled, J. Sharpe, R.M. Henkelman. Resolution Improvement in Emission Optical Projection Tomography. Physics in Medicine and Biology 52:2775-2790, 2007.
DOI 10.1088/0031-9155/52/10/010

R. Williams, A. Needles, E. Cherin, Y-Q. Zhou, R.M. Henkelman, S.L. Adamson, F.S. Foster. Noninvasive Ultrasonic Measurement of Local Pulse-Wave Velocity in Mice. Ultrasound in Medicine and Biology 33(9):1368-1375, 2007.
DOI 10.1016/j.ultrasmedbio.2007.03.012

G. Xie, S. Clapcote, B. Nieman, T. Tallerico, Y. Huang, I. Vukobradovic, S. Cordes, L. Osborne, J. Rossant, J.G. Sled, J. Henderson, J.C. Roder. Forward Genetics Screen of Mouse Reveals Dominant Missense Mutation in the P/Q-type VDCC. Genes, Brain and Behavior 6(8):717-727, 2007.
DOI 10.1111/j.1601-183X.2007.00302x PMID 17376154

Y-Q. Zhou, R. Bishay, A. Feintuch, K Tao, F. Golding, W. Zhu, L.J. West, R.M. Henkelman. Morphological and Functional Observations of Murine Heterotypic Cardiac Isografts using Ultrasound Biomicroscopy. Ultrasound in Medicine and Biology 33(6):870-879, 2007.
DOI 10.1016/j.ultrasmedbio.2006.10.016


J. Bishop, A. Feintuch, J. Dazai, L. Davidson, R.M. Henkelman. Retrospective Gating for Mouse Cardiac MRI. Magnetic Resonance in Medicine 55:472-477, 2006.
DOI 10.1002/mrm.20794

N.A. Bock, N. Kovacevic, T.V. Lipina, J.C. Roder, S.L. Ackerman, R.M. Henkelman. InVivo Magnetic Resonance Imaging and Semi-Automated Image Analysis Extend the Brain Phenotype for cdf/cdf Mice. Journal of Neuroscience 26:4455-4459, 2006 (Cover Illustration).
DOI 10.1523/JNEUROSCI.5438-05.2006

X.J. Chen, R.M. Henkelman. Rapid phenotyping of mice with MRI. In: In Vivo MR Techniques in Drug Discovery and Development. Ed. Nicolau Beckmann, pp. 75-92. Boca Raton, FL: CRC Press/Taylor & Francis Group, 2006.

R.M. Henkelman, L. Baghdadi, J.G. Sled. Presentation of 3D Isotropic Imaging Data for Optimal Viewing. Magnetic Resonance in Medicine 56(6):1371-1374, 2006.
DOI 10.1002/mrm.21077

S. Kulandavelu, D. Qu, N. Sunn, J. Mu, M.Y. Rennie, K.J. Whiteley, J.R. Walls, N.A. Bock, J.C.H. Sun, A. Covelli, J.G. Sled, S.L. Adamson. Embryonic and Neonatal Phenotyping of Genetically Engineered Mice. ILAR Journal 47(2):103-117, 2006.
PMID 16547367

H. Lu, P.W.M. Fedak, X. Dai, C. Du, Y-Q, Zhou, M. Henkelman, P.S. Mongroo, A. Lau, H. Yamabi, A. Hinek, M. Husain, G. Hannigan, J.G. Coles. Integrin-Linked Kinase Expression is Elevated in Human Cardiac Hypertrophy and Induced Hypertrophy in Transgenic Mice. Circulation 114:2271-2279, 2006.
DOI 10.1161/CIRCULATIONAHA.106.642330

M. Marxen, C. Paget, L.X. Yu, R.M. Henkelman. Estimating Perfusion using MicroCT to Locate Microspheres. Physiology in Medicine and Biology 51:N9-N16, 2006.
DOI 10.1088/0031-9155/51/1/N02

M. Marxen, J.G. Sled, L.X. Yu, C. Paget, R.M. Henkelman. Comparing Microsphere Deposition and Flow Modeling in 3D Vascular Trees. American Journal of Physiology Heart and Circulatory Physiology 291(5):H2136-H2141, 2006.
DOI 10.1152/ajpheart.00146.2006

A.D. Mori, Y. Zhu, I. Vahora, B. Nieman, K. Koshiba-Takeuchi, L. Davidson, A. Pizard, C.E. Seidman, X.J. Chen, R.M. Henkelman, B.G. Bruneau. Tbx5-Dependent Rheostatic Control of Cardiac Gene Expression and Morphogenesis. Developmental Biology 297:566-586, 2006.
DOI 10.1016/j.ydbio.2006.05.023

B.J. Nieman, A.M. Flenniken, S.L. Adamson, R.M. Henkelman, J.G. Sled. Anatomical Phenotyping in the Brain and Skull of Mutant Mice by Magnetic Resonance Imaging and Computed Tomography. Physiological Genomics 24:154-162, 2006 (Cover Illustration).
DOI 10.1152/physiolgenomics.00217.2005

Q. Wei, L. Clarke, D.K. Scheidenhelm, B. Qian, A. Tang, N. Sabha, Z. Karim, N.A. Bock, R. Reti, R. Swoboda, E. Purev, J-F. Lavoie, M.L. Bajenaru, P. Shannon, D. Herlyn, D. Kaplan, R.M. Henkelman, D.H. Gutmann, A. Guha. High-Grade Glioma Formation Results from Postnatal Pten Loss or Mutant Epidermal Growth Factor Receptor Expression in a Transgenic Mouse Glioma Model. Cancer Research 66:7429-7437, 2006.
DOI 10.1158/0008-5472CAN-0600712


R. Behin, J. Bishop, R.M. Henkelman. Dynamic Range Requirements for MRI. Concepts of Magnetic Resonance, Part B: Magnetic Resonance Engineering 26B(1):28-35, 2005.
DOI 10.1002/cmr.b.20042

N.A. Bock, B.J. Nieman, J.B. Bishop, R.M. Henkelman. In Vivo Multiple-Mouse MRI at 7 Tesla. Magnetic Resonance in Medicine 54(5):1311-1316, 2005.
DOI 10.1002/mrm.20683

X.J. Chen. Mouse morphological phenotyping with MRI. In: Magnetic Resonance Imaging: Methods and Biological Applications. Ed. Pottumarthi V. Prasad. Totowa NJ: Humana Press, 2005.

X.J. Chen, N. Kovacevic, N.J. Lobaugh, J.G. Sled, R.M. Henkelman, J.T. Henderson. Neuroanatomical Differences between Mouse Strains as Shown by High-Resolution 3D MRI. NeuroImage 29(1):99-105, 2005 (Cover Illustration).
DOI 10.1016/j.neuroimage.2005.07.008

A.M. Flenniken, L.R. Osborne, N. Anderson, N. Ciliberti, C. Fleming, J.E.I. Gittens, X-Q. Gong, L.B. Kelsey, C. Lounsbury, L. Moreno, B.J. Nieman, K. Paterson, D. Qu, W. Roscoe, Q. Shao, D. Tong, G.I.L. Veitch, I. Voronina, I. Vukobradovic, G.A. Wood, Y. Zhu, R.A. Zirngibl, J.E. Aubin, D. Bai, B.G. Bruneau, M. Grynpas, J.E. Henderson, R.M. Henkelman, C. McKerlie, J.G. Sled, W.L. Stanford, D.W. Laird, G.M. Kidder, S.L. Adamson, J. Rossant. A Gja1 Missense Mutation in a Mouse Model of Oculodentodigital Dysplasia (ODDD). Development 132(19):4375-4386, 2005.
PMID 16155213

R.M. Henkelman, X.J. Chen, J.G. Sled. Disease phenotyping: structural and functional readouts. In: Imaging in Drug Discovery and Early Clinical Trails. Ed. Marcus Rudin, pp153-184. Berlin: Birkhäuser Verlag, 2005.

N. Kovacevic, J.T. Henderson, E. Chan, N. Lifshitz, J. Bishop, A.C. Evans, R.M. Henkelman, X.J. Chen. A 3D Atlas of the Mouse Brain with Estimates of the Average and Variability. Cerebral Cortex 15(5):639-645, 2005.
DOI 10.1093/cercor/bhh165

B.J. Nieman, J. Bishop, R.M. Henkelman. Gradient Hysteresis in MRI and NMR Experiments. Journal of Magnetic Resonance 177(2):336-340, 2005.
DOI 10.1016/j.jmr.2005.08.012

B.J. Nieman, N.A. Bock, J. Bishop, X.J. Chen, J.G. Sled, J. Rossant, R.M. Henkelman. Magnetic Resonance Imaging for Detection and Analysis of Mouse Phenotypes. NMR in Biomedicine 18(7):447-468, 2005.
DOI 10.1002nbm.981

B.J. Nieman, N.A. Bock, J. Bishop, J.G. Sled, X.J. Chen, R.M. Henkelman. Fast Spin-Echo for Multiple Mouse MR Phenotyping. Magnetic Resonance in Medicine 54:532-537, 2005.
DOI 10.1002/mrm.20590

J.K. Takeuchi, M. Mileikovskaia, K. Koshiba-Takeuchi, A.B. Heidt, A.D. Mori, E.P. Arruda, M. Gertsenstein, R. Georges, L. Davidson, R. Mo, C-C. Hui, R.M. Henkelman, M. Nemer, B.L. Black, A. Nagy, B.G. Bruneau. Tbx20 Dose-Dependently Regulates Transcription Factor Networks Required for Mouse Heart and Motor Neuron Development. Development 132(10):2463-2474, 2005.
PMID 18378906

J.R. Walls, J.G. Sled, J. Sharpe, R.M. Henkelman. Correction of Artefacts in Optical Projection Tomography. Physics in Medicine and Biology 50(19):4645-4665, 2005.
DOI 10.1088/0031-551/50/19/015

Y-Q. Zhou, Y. Zhu, J. Bishop, L. Davidson, R.M. Henkelman, B.G. Bruneau, F.S. Foster. Abnormal Cardiac Inflow Patterns during Postnatal Development in a Mouse Model of Holt-Oram Syndrome. American Journal of Physiology Heart Circulation and Physiology 289(3):H992-H1001, 2005.
DOI 10.1152/ajphear.00027.2005


C. Akirav, Y. Lu, J. Mu, D.W. Qu, Y.Q. Zhou, J. Slevin, D. Holmyard, F.S. Foster, S.L. Adamson. Ultrasonic Detection and Developmental Changes in Calcification of the Placenta During Normal Pregnancy in Mice. Placenta 26(2-3):129-137, 2004.
DOI 10.1016/j.placenta.2004.05.010

J. Dazai, N.A. Bock, B.J. Nieman, L.M. Davidson, R.M. Henkelman, X.J. Chen. Multiple Mouse Biological Loading and Monitoring System for MRI. Magnetic Resonance in Medicine 52(4):709, 2004.
DOI 10.1002/mrm.20215

N. Kovacevic, J. Chen, J.G. Sled, J. Henderson, M. Henkelman. Deformation Based Representation of Groupwise Average and Variability. Medical Imaging Computing and Computer-Assisted Intervention. Lecture Notes in Computer Science 3217:615-622, 2004.
DOI 10.1007/b100265

H. Lickert, J.K. Takeuchi, I. von Both, J.R. Walls, F. McAuliffe, S.L. Adamson, R.M. Henkelman, J.L. Wrana, J. Rossant, B.G. Bruneau. Baf60c Is Essential for Function of BAF Chromatin Remodeling Complexes in Heart Development. Nature 432(7013):107-112, 2004.
DOI 10.1038/nature.03071

M. Marxen, M.M. Thornton, C.B. Chiarot, G. Klement, J. Koprivnikar, J.G. Sled, R.M. Henkelman. MicroCT Scanner Performance and Considerations for Vascular Specimen Imaging. Medical Physics 31(2):305-313, 2004.
DOI 10.1118/1.163791

S.K. Singh, C. Hawkins, I.D. Clarke, J.A. Squire, J. Bayani, T. Hide, R.M. Henkelman, M.D. Cusimano, P.B. Dirks. Identification of Human Brain Tumour Initiating Cells. Nature 432(7015):396-401, 2004.
DOI 10.1031/nature03031

J.G. Sled, M. Marxen, R.M. Henkelman. Analysis of micro-vasculature in whole kidney specimens using micro-CT. 40 th Annual Meeting of the SPIE, International Symposium on Optical Science and Technology. In: Proceedings of the SPIE 5535:53-64, 2004.
DOI 10.1117/12.559731

I. von Both, C. Silvestri, T. Erdemir, H. Lickert, J.R. Walls, R.M. Henkelman, J. Rossant, R.P. Harvey, L. Attisano, J.L. Wrana. Foxh1 Is Essential for Development of the Anterior Heart Field. Developmental Cell 7(3):331-345, 2004.
PMID 17568773

N.L. Ward, A.L. Haninec, P. Van Slyke, J.G. Sled, C. Sturk, R.M. Henkelman, I.R. Wanless, D.J. Dumont. Angiopoietin-1 Causes Reversible Degradation of the Portal Microcirculation in Mice: Implications for Treatment of Liver Disease. American Journal of Pathology 165(3):889-899, 2004.
PMID 15331413

Y-Q. Zhou, L. Davidson, R.M. Henkelman, B.J. Nieman, F.S. Foster, L.X. Yu, X.J. Chen. Ultrasound-Guided Left Ventricular Catheterization: A Novel Method of Whole Mouse Perfusion for Microimaging. Laboratory Investigation 84(3):385-389, 2004.
DOI 10.1038/labinvest.3700038

Y-Q Zhou, F.S. Foster, B.J. Nieman, L. Davidson, X.J. Chen, R.M. Henkelman. Comprehensive Transthoracic Cardiac Imaging in Mice using Ultrasound Biomicroscopy with Anatomical Confirmation by Magnetic Resonance Imaging. Physiological Genomics 18(2):232-244, 2004.
DOI 10.1152/physiologicalgenomics.00026.2004


N.A. Bock, N.B. Konyer, R.M. Henkelman. Multiple-Mouse MRI. Magnetic Resonance in Medicine 49(1):158-167, 2003.
DOI 10.1002/mrm.10326

N.A. Bock, G. Zadeh, L.M. Davidson B. Qian, J.G. Sled, R.M. Henkelman, A. Guha. High-Resolution Longitudinal Screening with Magnetic Resonance Imaging in a Murine Brain Cancer Model. Neoplasia 5(6):546-554, 2003.
PMCID PMC1502570

G. Hamarneh, J. Chen, B. Neiman, J. Henderson, M. Henkelman. Segmentation, Registration, and Deformation Analysis of 3D MR Images of Mice. Medical Imaging Computing and Computer-Assisted Intervention. Lecture Notes in Computer Science 2879:878-885, 2003.
DOI 10.1007/b93811

R. Karshafian, P.N. Burns, R.M. Henkelman. Transit Time Kinetics in Ordered and Disordered Vascular Trees. Physiology in Medicine and Biology 48:3225-3237, 2003.
DOI 10.1088/003-9155/48/19/009

N. Kovacevic, G. Hamarneh, M. Henkelman. Anatomically Guided Registration of Whole Body Mouse MR Images. Medical Imaging Computer and Computer-Assisted Intervention. Lecture Notes in Computer Science 2879:870-877, 2003.
DOI 10.1007/b93811

M. Marxen, R.M. Henkelman. Branching Tree Model with Fractal Vascular Resistance Explains Fractal Perfusion Heterogeneity. American Journal of Physiology Heart Circulation and Physiology 284:H1848-H1857, 2003.
DOI 10.1152/ajpheart.00510.2002

W.R. van Furth, S. Laughlin, M.D. Taylor, B. Salhia, T. Mainprize, M. Henkelman, M.D. Cusimano, C. Ackerley, J.T. Rutka. Imaging of Murine Brain Tumors using a 1.5 Tesla Clinical MRI System. Canadian Journal of Neurological Science 30:326-332, 2003.
PMID 14672264

Y.Q. Zhou, F.S. Foster, R. Parkes, S.L. Adamson. Developmental Changes in Left and Right Ventricular Diastolic Filling Patterns in Mice. American Journal of Physiology Heart Circulation and Physiology 285(4):H1563-1575, 2003.
DOI 10.1152/ajpheart.00384.2003


Y.Q. Zhou, F.S. Foster, D.W. Qu, M. Zhang, K.A. Harasiewicz, S.L. Adamson. Applications for Multifrequency Ultrasound Biomicroscopy in Mice from Implantation to Adulthood. Physiological Genomics 10(2):113-126, 2002.
DOI 10.1152/physiolgenomics.00119.2001

Canadian Mouse Mutant Repository (CMMR)


Yildiz C, Law N, Ottaviani P, Jarvi K, McKerlie C. Comparison of sperm quality and DNA integrity in mouse sperm exposed to various cooling velocities and osmotic stress. Theriogenol (epublished ahead of print doi:10.1016/j.theriogenology.2010.06.014, 21 August 2010).

Gertsenstein M, Nutter LMJ., Reid T, Pereira M, Stanford WL, Rossant J, Nagy A. Efficient generation of germ line transmitting chimeras from C57BL/6N ES cells by aggregation with outbred host embryos. PLoS one 5 (6): e11260. June 2010.


Liu L, Nutter LM, Law N, McKerlie C. Sperm freezing and in vitro fertilization in three sub-strains of C57BL/6 mice. J Am Assoc Lab Anim Sci 48 (1): 39-43. January 2009.


Yildiz C, Fleming C, Ottaviani P, McKerlie C. Fresh and frozen-thawed sperm quality, nuclear DNA integrity, in vitro fertility, and embryo development to live-born offspring of N-ethyl-N-nitrosourea (ENU) mice. Cryobiol 57 (2): 156-162. October 2008.

McKerlie C. The Toronto Centre for Phenogenomics: Innovation in facility design, equipment, technologies, and research services to enable the best transgenic science. Transgenic Res 17 (5): 1001. October 2008.

McKerlie C, Nutter L, Zitano L. Cryopreservation, archiving, and distribution to support functional annotation of the mouse genome: A role for the Canadian Mouse Mutant Repository in the International Knockout Mouse Consortium. Cell Pres Tech 6 (2): 144. June 2008.

Liu L, Wood G, Morikawa L, Ayearst R, Fleming C, McKerlie C. Restoration of fertility by orthotopic transplantation of frozen adult mouse ovaries. Human Repro 23(1): 122-128. January 2008.


Yildiz C, Ayearst R, Law N, Liu L, Ottaviani P, McKerlie C. Effects of cryopreservation on sperm quality, nuclear DNA integrity, in vitro fertilization, and in vitro embryo development in the mouse. Reproduction 133(3): 585-595. March 2007.


Yildiz C, Ayearst R, Law N, Liu L, Ottaviani P, McKerlie C. Effects on sperm cryopreservation, nuclear DNA integrity, invitro fertility, and embryo development of combined permeating and non-permeating cryoprotectants in hybrid, outbred, and inbred mice. Reproduction (in press) December 2006.


Yildiz C, Ayearst R, Law N, Liu L, Ottaviani P, McKerlie C. Effects of combined permeating and non-permeating cryoprotectants on sperm quality, DNA integrity and in vitro fertility on different mouse strains. 19th International Mouse Genome Conference, Strasbourg, France. November 2005.


McKerlie C, Ayearst R, Fleming C, Liu L, Ottaviani P, Yildiz C. The Canadian Mouse Mutant Repository: A germ cell, embryo, and tissue biorepository for functional annotation of the genome. Cell Pres Tech 2 (4): 298-339. December 2004.

Yildiz C, Fleming C, Cao A, McKerlie C. Fresh and cryopreserved sperm quality, DNA integrity, and in vitro fertility in two hybrid strains of N-ethyl-N-nitrosourea (ENU) mice. 18th International Mouse Genome Conference, Seattle, Washington, USA. October 2004.

McKerlie C, Ayearst R, Fleming C, Liu L, Ottaviani P, Yildiz C. The Canadian Mouse Mutant Repository: A germ cell, embryo, and tissue biorepository for functional annotation of the genome. International Society for Biological and Environmental Repositories (ISBER) Meeting 2004, University of Perugia, Perugia, Italy. October 2004.

McKerlie C. Canadian repository resources: What the Canadian Mouse Mutant Repository can contribute to the international mouse archive. Mouse Mutagenesis Meeting, London, UK. October 2004.

McKerlie C, Ayearst R, Fleming C, Liu L, Ottaviani P, Yildiz C. The Canadian Mouse Mutant Repository: A germ cell, embryo, genome, and tissue biorepository. 2nd Annual Eumorphia Meeting, Slough, UK. October 2004.

McKerlie C. Pathology phenotyping and repository resources: What the Canadian Mouse Consortium can contribute to the international mouse knockout initiative. 1st Canadian Mouse Consortium Symposium, Winnipeg, Canada. September 2004.

McKerlie C, Ayearst R, Fleming C, Liu L, Ottaviani P, Yildiz C. High-throughput germ cell, embryo, and tissue DNA archiving for ENU mutagenesis. 2004 International Society for Biological and Environmental Repositories. New York City, New York, USA. May 2004.

Kanter M, Yildiz C, Meral I, Koc A, Tasal I. Effects of a GnRH agonist on oocyte number and maturation in mice superovulated with eCG and hCG. Theriogenology 15;61(2-3):393-8. January 2004.

Centre for Modelling Human Disease (CMHD)


Adissu H, Fang H, McKerlie C, Khokha R, Wood G. Tissue inhibitor of metalloprotease-3 (TIMP3) deficiency promotes invasive prostatic carcinoma. 1st Cancer Research Symposium, The Institute for Comparative Cancer Investigation, University of Guelph, Guelph, Canada. June 2010.

Adissu HA, McKerlie C, Khokha R, Wood GA. Tissue inhibitor of metallopreotease-3 (TIMP3) deficiency promotes invasive prostate adenocarcinoma. The Hospital for Sick Children Physiology & Experimental Medicine Research Program Scientific Retreat, Toronto, Canada. March 2010.

Wang Y, Newbigging S, Morikawa L, McKerlie C. Fixation and perfusion of the mouse. The Hospital for Sick Children Physiology & Experimental Medicine Research Program Scientific Retreat, Toronto, Canada. March 2010.


Schofield PN, et al., McKerlie C, et al. (CASIMIR Meeting Rome Participants). Opinion - Post-publication sharing of data and tools. Nature 461 (7260): 171-173. 10 September 2009.

Ng D, Pitcher GM, Szilard RK, Sertié A, Kanisek M, Clapcote SJ, Lipina T, Kalia LV, Joo D, McKerlie C, Cortez M, Roder JC, Salter MW, McInnes RR. Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning. PLoS Biol 7 (2): e1000041. February 2009.

Schofield PN, Brown SDM, Sundberg JP, Warren M, Dubus P, Ellender M, Fiette L, Rozell B, Quintanilla-Martinez L, Raspa M, Song J-Y, van der Valk M, Arends M, McKerlie C. Letter to the Editor - PRIME importance of pathology expertise. Nat Biotechnol 27 (1): 24-25. January 2009.


Deng H, Tang N, Stief AE, Mehta N, Baig E, Head R, Sleep G, Yang XZ, McKerlie C, Trudel S, Stewart AK, McCart JA. Oncolytic virotherapy for multiple myeloma using a tumour-specific double-deleted vaccinia virus. Leukemia 22 (12): 2261-2264. December 2008.

Yang Y, McKerlie C, Wang LC, Lu Zhan, Buchwald M. In vivo potential effects of adenovirus type 5 E1A and E1B on lung carcinogenesis and lymphoproliferative inflammation. J Virol 82 (16): 8105-8111. August 2008.

Grasso F, Engelberts D, Helm E, Frndova H, Jarvis S, McKerlie C, Babyn P, Post M, Kavanagh BP. Negative-pressure ventilation: Better oxygenation and less lung injury. Am J Respir Crit Care Med 177(4): 412-418. February 2008.

Nemati B, Atmodjo W, Gagnon S, Humes D, McKerlie C, Kaplan F, Sweezey NB. Glucocorticoid receptor disruption delays structural maturation in the lungs of newborn mice. Pediatr Pulmon 43(2): 125-133. February 2008.


Lee SU, Grigorian A, Pawling J, Chen IJ, Gao G, Mozaffar T, Mckerlie C, Demetriou M. N-glycan processing deficiency promotes spontaneous inflammatory demyelination and neurodegeneration. J Biol Chem 282(46): 33725-34. November 2007.

Chen N-J, Mirtsos C, Suh D, Lu Y-C, Lin W-J, McKerlie C, Lee T, Baribault H, Tian H, Yeh W-C. C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a. Nature 446 (71322): 203-207. March 2007.

Roth-Kleiner M, Ridsdale R, Cao L, Kuliszewski M, Tseu I, McKerlie C, Post M. Lipopolysaccharide exposure modifies high tidal volume ventilation-induced proinflammatory mediator expression in newborn rat lungs. Ped Res 61(2): 191-196. February 2007.

Tremblay LO, Kovács EN, Daniels E, Wong NK, Sutton-Smith M, Morris HR, Dell A, Marcinkiewicz E, Seidah NG, McKerlie C, Herscovics A. Respiratory distress and neonatal lethality in mice lacking Golgi ?1,2-mannosidase IB involved in N-glycan maturation. J Biol Chem 282 (4): 2558-2566. January 2007.


Meyer J, Cox PN, McKerlie C, Bienzle D. High frequency oscillatory ventilation in a rabbit model. Ped Res 60 (4): 401-406. October 2006.

Tsuchida S, Engelberts D, Peltekova V, Hopkins N, Frndova H, Babyn P, McKerlie C, Post M, McLoughlin P, Kavanagh BP. Atelectasis causes alveolar injury in non-atelectatic lung regions. Am J Respir Crit Care Med 174 (3): 279-289. August 2006.

Caron J, Lariviére L, Nacache M, Tam M, Stevenson MM, McKerlie C, Gros P, Malo D. Influence of Slc11a1 on the outcome of Salmonella enterica serovar enteritidis infection in mice is associated with Th polarization. Infect Immun 74 (5): 2787-2802. May 2006.

Gagnon S, Atmodjo W, Humes D, McKerlie C, Kaplan F, Sweezey NB. Transgenic glucocorticoid receptor expression driven by the SP-C promoter reduces neonatal lung cellularity and midkine expression in GRhypo mice. Biol Neonate 90 (1): 46-57. March 2006.

McKerlie C. Cause and effect considerations in pathology diagnosis and pathology phenotyping of genetically engineered mice. ILAR J (Nat Acad Sci) 47 (2): 155-161. March 2006.

Wang Y, Morikawa L, McKerlie C. Laser capture microdissection: Getting it to work. 32nd Annual Meeting of the National Society of Histotechnology, San Antonio, USA. September 2006.

McKerlie C. Toronto Centre for Phenogenomics. 45th Annual Meeting Canadian Society for Laboratory Animal Science (CALAS), Montreal, Canada. April 2006.


Wang Y, Vachon E, Zhang J, Cherepanov V, Kruger J, Li J, Saito K, Shannon P, Bottini N, Huynh H, Ni H, Yang H, McKerlie C, Quaggin S, Zhao ZJ, Marsden PA, Mustelin T, Siminovitch K, Downey G. Tyrosine phosphatase MEG2 modulates murine development and platelet and lymphocyte activation through secretory vesicle function. J Exp Med 202 (11): 1587-1597. December 2005.

Koehler DR, Frndova H, Leung K, Louca E, Palmer D, Ng P, McKerlie C, Cox P, Coates A, Hu J. Aerosol delivery of an enhanced adenoviral formulation to rabbit lung with an intratracheal catheter. J Gene Med 7(11):1409-20. November 2005.

Flenniken AM, Osborne LR, Anderson N, Ciliberti N, Fleming C, Gittens JEI, Gong X-Q, Lounsbury C, Moreno L, Nieman BJ, Peterson K, Qu D, Roscoe W, Shao Q, Tong D, Veitch GIL, Voronina I,Vukobradovic I, Wood G, Zhu Y, Zirngibl RA, Aubin JE, Bai D, Bruneau BG, Grynpas M, Henderson J, Henkelman RM, McKerlie C, Sled JG, Stanford WL, Laird DW, Kidder GM, Adamson SL, Rossant J. A Gja1 missense mutation in a mouse model of Oculodentodigital Dysplasia (ODDD). Development 132 (19): 4375-4386. October 2005.

Tsuchida S, Engelberts D, Roth M, McKerlie C, Post M, Kavanagh BP. Continuous positive airway pressure causes lung injury in a model of sepsis. Am J Physiol Lung Cell Mol Physiol 289 (4): L554-L564. October 2005.

Wood G, Fleming C, Flenniken A, Kassam N, Morikawa L, Porter R, Rossant J, McKerlie C. Two mouse mutations mapped to chromosome 11 with differing morphologies, but similar progressive inflammatory alopecia. Exp Derm 14 (5): 373-379. May 2005.

Kornecki A, Tsuchida S, Ondiveeran HK, Engelberts D, Frndova H, Tanswell AK, Post M, McKerlie C, Belik J, Fox-Robichaud A, Kavanagh BP. Lung development and susceptibility to ventilator-induced lung injury. Am J Resp Crit Care Med 171 (7): 743-752. April 2005.

Gawlik A, Berberovic Z, Wood GA, Flenniken A, Osborne L, Fleming C, Vukobradovic I, McKerlie C, Adamson L, Rossant J, Quaggin SE. Nephrol Dialysis Transplantation 5 (20): 199. June 2005.

Healy A, McKerlie C. Acute Antigen Sensitized Model of Airway Hyper response & Asthma-like Inflammation. The Hospital for Sick Children Research Institute Summer Student Research Day, Toronto, Canada. June 2005.


Serbanescu I, Cortez MA, McKerlie C, OC Snead III. Refractory atypical absence seizures in rat: A two hit model. Epilepsy Res 62 (1): 53-63. November 2004.

McKerlie C, Ayearst R, Fleming C, Liu L, Ottaviani P, Yildiz C. The Canadian Mouse Mutant Repository: A germ cell, embryo, genome, and tissue biorepository. EUMORPHIA 2nd General Assembly, Munich, Germany. October 2004.

Tribl B, Filipp D, Bödeker H, Yu P, Hammerrmüller I, McKerlie C, Keim V, Sibbald WJ. Pseudomonas pneumonia-mediated sepsis induces expression of pancreatitis-associated protein-I in rat pancreas. Pancreas 29 (1): 33-40. July 2004.

Copland IB, Martinez F, Kavanagh BP, Belik J, Engelberts D, McKerlie C, Post M. High tidal volume ventilation causes different inflammatory responses in newborn versus adult lung. Am J Respir Crit Care Med 169 (6): 739-48. March 2004.

Chow RL, Volgyi B, Szilard RK, Ng D, McKerlie C, Bloomfield SA, Birch DG, McInnes RR. Control of late off-center cone bipolar cell differentiation and visual signaling by the homeobox gene Vsx1. PNAS 101 (6): 1754-9. February 2004.

Koehler DR, Sajjan U, McKerlie C, Coates, AL, Tanswell AK, Forstner JF, Hu J. Epithelium-specific gene therapy vector protects cftr knockout mice from acute lung infection. Mol Therapy 9, Supplement 1: S260. June 2004.

Kornecki K, Tsuchida S, Engelberts D, Frndova H, McKerlie C, Belik J, Fox-Robichaud A, Kavanagh BP. Ventilator-associated lung injury - Are infants as susceptible as adults? Am J Resp Crit Care Med 169 (7): A787. April 2004.


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