Glossary

Many phrases and terms are used in the policies and procedures. Please refer to the following list for clarification.

CFI	Canada Foundation for Innovation
CMHD	Centre for Modeling Human Disease
CMMR	Canadian Mouse Mutant Repository
DI	Depositing Investigator
	The researcher or institution submitting mutants or samples to the CMMR.
ENU	N-ethyl-N-nitrosourea
FIMRe	Federation of Internation Mouse Resources
	Alkylating mutagen that induces random point mutations.
ICSI	Intracytoplasmatic Sperm Injection
	The process by which a single spermatozoan is mechanically inserted into a donor oocyte in order to induce fertilization. Usually of choice for the rescue effort for males with poor quality sperm.
IMMF	International Mouse Mutagenesis Federation
IS	Inbred Strain (congenic)
	A group of organisms so highly inbred as to be genetically identical, except for sexual differences. Brother sister matings for 20 or more generations are required before a strain can be defined as ‘inbred’.
IVF	In Vitro Fertilization
	The process by which mature oocytes from superovulated female mice are fertilized in a Petri dish with epididymal sperm. Rescue effort for ill, aged unproductive males.
KO	Knock Out
	A mutant mouse containing a null allele for a gene under study, generated by homologous recombination in embryonic stem cells.
MICe	Mouse Imaging Centre
MTA	Material Transfer Agreement
	Agreement authorizes transfers of mice or cryopreserved samples between the donating investigator and the CMMR (Donor MTA) and the CMMR and requesting investigator (Requesting MTA).
OIT	Ontario Innovation Trust
	Ovarian Transplantation
	Generation of offspring using cryopreserved ovaries. Rescue effort perfomed for aged, ill or unproductive females.
PI	Principal Investigator
	The senior researcher of an institution responsible for the project.
	Rederivation
	The transfer of frozen or fresh embryos for transplantation in recipient females in order to generate a specific strain.
	Sperm Assessment
	Comprehensive sperm analysis that includes sperm concentration, sperm motility and sperm viability.
TCP	Toronto Centre for Phenogenomics
TG	Transgenics
	Animals into which cloned genetic material has been experimentally transferred.
WI	Withdrawing Investigator
	The researcher or institution requesting a sample from the CMMR.