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Glossary

Many phrases and terms are used in the policies and procedures. Please refer to the following list for clarification.

CFI Canada Foundation for Innovation
CMHD Centre for Modeling Human Disease
CMMR Canadian Mouse Mutant Repository
DI Depositing Investigator
The researcher or institution submitting mutants or samples to the CMMR.
ENU N-ethyl-N-nitrosourea
FIMRe Federation of Internation Mouse Resources
Alkylating mutagen that induces random point mutations.
ICSI Intracytoplasmatic Sperm Injection
The process by which a single spermatozoan is mechanically inserted into a donor oocyte in order to induce fertilization. Usually of choice for the rescue effort for males with poor quality sperm.
IMMF International Mouse Mutagenesis Federation
IS Inbred Strain (congenic)
A group of organisms so highly inbred as to be genetically identical, except for sexual differences. Brother sister matings for 20 or more generations are required before a strain can be defined as ‘inbred’.
IVF In Vitro Fertilization
The process by which mature oocytes from superovulated female mice are fertilized in a Petri dish with epididymal sperm. Rescue effort for ill, aged unproductive males.
KO Knock Out
A mutant mouse containing a null allele for a gene under study, generated by homologous recombination in embryonic stem cells.
MICe Mouse Imaging Centre
MTA Material Transfer Agreement
Agreement authorizes transfers of mice or cryopreserved samples between the donating investigator and the CMMR (Donor MTA) and the CMMR and requesting investigator (Requesting MTA).
OIT Ontario Innovation Trust
  Ovarian Transplantation
Generation of offspring using cryopreserved ovaries. Rescue effort perfomed for aged, ill or unproductive females.
PI Principal Investigator
The senior researcher of an institution responsible for the project.
  Rederivation
The transfer of frozen or fresh embryos for transplantation in recipient females in order to generate a specific strain.
  Sperm Assessment
Comprehensive sperm analysis that includes sperm concentration, sperm motility and sperm viability.
TCP Toronto Centre for Phenogenomics
TG Transgenics
Animals into which cloned genetic material has been experimentally transferred.
WI Withdrawing Investigator
The researcher or institution requesting a sample from the CMMR.

 

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