The Centre for Phenogenomics
The Centre for Phenogenomics

Publications

Publications made possible by The Centre for Phenogenomics

2017

Allemang-Grand, R., J. Ellegood, L. Spencer Noakes, J. Ruston, M. Justice, B. J. Nieman and J. P. Lerch (2017). "Neuroanatomy in mouse models of Rett syndrome is related to the severity of Mecp2 mutation and behavioral phenotypes." Mol Autism 8: 32. (co-authored by Mouse Imaging Centre staff)

Baht, G. S., P. Nadesan, D. Silkstone and B. A. Alman (2017). "Pharmacologically targeting beta-catenin for NF1 associated deficiencies in fracture repair." Bone 98: 31-36.

Blanco, A. M., M. Gomez-Boronat, A. L. Alonso-Gomez, R. Yufa, S. Unniappan, M. J. Delgado and A. I. Valenciano (2017). "Characterization of Ghrelin O-Acyltransferase (GOAT) in goldfish (Carassius auratus)." PLoS One 12(2): e0171874.

Cahill, L. S., J. Bishop, L. M. Gazdzinski, A. Dorr, B. Stefanovic and J. G. Sled (2017). "Altered cerebral blood flow and cerebrovascular function after voluntary exercise in adult mice." Brain Struct Funct. (co-authored by Mouse Imaging Centre staff)

Cahill, L. S., L. M. Gazdzinski, A. K. Tsui, Y. Q. Zhou, S. Portnoy, E. Liu, C. D. Mazer, G. M. Hare, A. Kassner and J. G. Sled (2017). "Functional and anatomical evidence of cerebral tissue hypoxia in young sickle cell anemia mice." J Cereb Blood Flow Metab 37(3): 994-1005. (co-authored by Mouse Imaging Centre staff)

Calamita, P., A. Miluzio, A. Russo, E. Pesce, S. Ricciardi, F. Khanim, C. Cheroni, R. Alfieri, M. Mancino, C. Gorrini, G. Rossetti, I. Peluso, M. Pagani, D. L. Medina, J. Rommens and S. Biffo (2017). "SBDS-Deficient Cells Have an Altered Homeostatic Equilibrium due to Translational Inefficiency Which Explains their Reduced Fitness and Provides a Logical Framework for Intervention." PLoS Genet 13(1): e1006552.

Capurro, M., T. Izumikawa, P. Suarez, W. Shi, M. Cydzik, T. Kaneiwa, J. Gariepy, L. Bonafe and J. Filmus (2017). "Glypican-6 promotes the growth of developing long bones by stimulating Hedgehog signaling." J Cell Biol.

Chi, L., A. Ahmed, A. R. Roy, S. Vuong, L. S. Cahill, L. Caporiccio, J. G. Sled, I. Caniggia, M. D. Wilson and P. Delgado-Olguin (2017). "G9a controls placental vascular maturation by activating the Notch Pathway." Development 144(11): 1976-1987. (co-authored by Mouse Imaging Centre staff)

Du Toit, E., L. Browne, H. Irving-Rodgers, H. M. Massa, N. Fozzard, M. P. Jennings and I. R. Peak (2017). "Effect of GPR84 deletion on obesity and diabetes development in mice fed long chain or medium chain fatty acid rich diets." Eur J Nutr.

Farah, O., S. Biechele, J. Rossant and D. Dufort (2017). "Porcupine-dependent Wnt signaling controls stromal proliferation and endometrial gland maintenance through the action of distinct WNTs." Dev Biol 422(1): 58-69.

Farkona, S., A. Soosaipillai, P. Filippou, D. Korbakis, S. Serra, F. Ruckert, E. P. Diamandis and I. M. Blasutig (2017). "Generation of monoclonal antibodies and development of an immunofluorometric assay for the detection of CUZD1 in tissues and biological fluids." Clin Biochem.

Feldcamp, L. A., P. C. Boutros, R. Raymond, P. J. Fletcher, J. N. Nobrega and A. H. C. Wong (2017). "Pdxdc1 modulates prepulse inhibition of acoustic startle in the mouse." Transl Psychiatry 7(5): e1125.

Filippou, P., D. Korbakis, S. Farkona, A. Soosaipillai, T. Karakosta and E. P. Diamandis (2017). "A new enzyme-linked immunosorbent assay (ELISA) for human free and bound kallikrein 9." Clin Proteomics 14: 4.

Geyer, S. H., L. Reissig, J. Rose, R. Wilson, F. Prin, D. Szumska, R. Ramirez-Solis, C. Tudor, J. White, T. J. Mohun and W. J. Weninger (2017). "A staging system for correct phenotype interpretation of mouse embryos harvested on embryonic day 14 (E14.5)." J Anat 230(5): 710-719.

Ghugre, N. R., M. Pop, R. Thomas, S. Newbigging, X. Qi, J. Barry, B. H. Strauss and G. A. Wright (2017). "Hemorrhage promotes inflammation and myocardial damage following acute myocardial infarction: insights from a novel preclinical model and cardiovascular magnetic resonance." J Cardiovasc Magn Reson 19(1): 50. (co-authored by TCP staff)

Hall, E. A., M. S. Nahorski, L. M. Murray, R. Shaheen, E. Perkins, K. N. Dissanayake, Y. Kristaryanto, R. A. Jones, J. Vogt, M. Rivagorda, M. T. Handley, G. R. Mali, T. Quidwai, D. C. Soares, M. A. Keighren, L. McKie, R. L. Mort, N. Gammoh, A. Garcia-Munoz, T. Davey, M. Vermeren, D. Walsh, P. Budd, I. A. Aligianis, E. Faqeih, A. J. Quigley, I. J. Jackson, Y. Kulathu, M. Jackson, R. R. Ribchester, A. von Kriegsheim, F. S. Alkuraya, C. G. Woods, E. R. Maher and P. Mill (2017). "PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic Proteins." Am J Hum Genet 100(5): 706-724.

Huang, J., A. Khan, B. C. Au, D. L. Barber, L. Lopez-Vasquez, N. L. Prokopishyn, M. Boutin, M. Rothe, J. W. Rip, M. Abaoui, M. S. Nagree, S. Dworski, A. Schambach, A. Keating, M. L. West, J. Klassen, P. V. Turner, S. Sirrs, C. A. Rupar, C. Auray-Blais, R. Foley and J. A. Medin (2017). "Lentivector Iterations and Pre-Clinical Scale-Up/Toxicity Testing: Targeting Mobilized CD34+ Cells for Correction of Fabry Disease." Mol Ther Methods Clin Dev 5: 241-258.

Johnson, L., B. Ganss, A. Wang, R. A. Zirngibl, D. E. Johnson, C. Owen, G. Bradley and I. Voronov (2017). "V-ATPases Containing a3 Subunit Play a Direct Role in Enamel Development in Mice." J Cell Biochem. (co-authored by TCP staff)

Karp, N. A., J. Mason, A. L. Beaudet, Y. Benjamini, L. Bower, R. E. Braun, S. D. M. Brown, E. J. Chesler, M. E. Dickinson, A. M. Flenniken, H. Fuchs, M. H. Angelis, X. Gao, S. Guo, S. Greenaway, R. Heller, Y. Herault, M. J. Justice, N. Kurbatova, C. J. Lelliott, K. C. K. Lloyd, A. M. Mallon, J. E. Mank, H. Masuya, C. McKerlie, T. F. Meehan, R. F. Mott, S. A. Murray, H. Parkinson, R. Ramirez-Solis, L. Santos, J. R. Seavitt, D. Smedley, T. Sorg, A. O. Speak, K. P. Steel, K. L. Svenson, C. International Mouse Phenotyping, S. Wakana, D. West, S. Wells, H. Westerberg, S. Yaacoby and J. K. White (2017). "Prevalence of sexual dimorphism in mammalian phenotypic traits." Nat Commun 8: 15475. (co-authored by TCP staff)

Kazazian, K., C. Go, H. Wu, O. Brashavitskaya, R. Xu, J. W. Dennis, A. C. Gingras and C. J. Swallow (2017). "Plk4 Promotes Cancer Invasion and Metastasis through Arp2/3 Complex Regulation of the Actin Cytoskeleton." Cancer Res 77(2): 434-447.

Kim, D. Y., J. Yu, R. K. Mui, R. Niibori, H. B. Taufique, R. Aslam, J. W. Semple and S. P. Cordes (2017). "The tyrosine kinase receptor Tyro3 enhances lifespan and neuropeptide Y (Npy) neuron survival in the mouse anorexia (anx) mutation." Dis Model Mech 10(5): 581-595.

Kim, J. J., T. Jiwani, S. Erwood, J. Loree and N. D. Rosenblum (2017). "Suppressor of fused controls cerebellar neuronal differentiation in a manner modulated by GLI3 repressor and Fgf15." Dev Dyn.

Korbakis, D., A. Soosaipillai and E. P. Diamandis (2017). "Study of kallikrein-related peptidase 6 (KLK6) and its complex with alpha1-antitrypsin in biological fluids." Clin Chem Lab Med.

Lai, M. C., J. P. Lerch, D. L. Floris, A. N. Ruigrok, A. Pohl, M. V. Lombardo and S. Baron-Cohen (2017). "Imaging sex/gender and autism in the brain: Etiological implications." J Neurosci Res 95(1-2): 380-397. (co-authored by Mouse Imaging Centre staff)

Lee, J., J. Koehler, B. Yusta, J. Bahrami, D. Matthews, M. Rafii, P. B. Pencharz and D. J. Drucker (2017). "Enteroendocrine-derived glucagon-like peptide-2 controls intestinal amino acid transport." Mol Metab 6(3): 245-255.

Leibinger, M., A. Andreadaki, R. Golla, E. Levin, A. M. Hilla, H. Diekmann and D. Fischer (2017). "Boosting CNS axon regeneration by harnessing antagonistic effects of GSK3 activity." Proc Natl Acad Sci U S A 114(27): E5454-E5463.

Lerch, J. P., A. J. van der Kouwe, A. Raznahan, T. Paus, H. Johansen-Berg, K. L. Miller, S. M. Smith, B. Fischl and S. N. Sotiropoulos (2017). "Studying neuroanatomy using MRI." Nat Neurosci 20(3): 314-326. (co-authored by Mouse Imaging Centre staff)

Logie, J., A. N. Ganesh, A. M. Aman, R. S. Al-Awar and M. S. Shoichet (2017). "Preclinical evaluation of taxane-binding peptide-modified polymeric micelles loaded with docetaxel in an orthotopic breast cancer mouse model." Biomaterials 123: 39-47.

Matsumoto, Y., J. La Rose, M. Lim, H. A. Adissu, N. Law, X. Mao, F. Cong, P. Mera, G. Karsenty, D. Goltzman, A. Changoor, L. Zhang, M. Stajkowski, M. D. Grynpas, C. Bergmann and R. Rottapel (2017). "Ubiquitin ligase RNF146 coordinates bone dynamics and energy metabolism." J Clin Invest 127(7): 2612-2625. (co-authored by TCP staff)

Meehan, T. F., N. Conte, D. B. West, J. O. Jacobsen, J. Mason, J. Warren, C. K. Chen, I. Tudose, M. Relac, P. Matthews, N. Karp, L. Santos, T. Fiegel, N. Ring, H. Westerberg, S. Greenaway, D. Sneddon, H. Morgan, G. F. Codner, M. E. Stewart, J. Brown, N. Horner, C. International Mouse Phenotyping, M. Haendel, N. Washington, C. J. Mungall, C. L. Reynolds, J. Gallegos, V. Gailus-Durner, T. Sorg, G. Pavlovic, L. R. Bower, M. Moore, I. Morse, X. Gao, G. P. Tocchini-Valentini, Y. Obata, S. Y. Cho, J. K. Seong, J. Seavitt, A. L. Beaudet, M. E. Dickinson, Y. Herault, W. Wurst, M. H. de Angelis, K. C. K. Lloyd, A. M. Flenniken, L. M. J. Nutter, S. Newbigging, C. McKerlie, M. J. Justice, S. A. Murray, K. L. Svenson, R. E. Braun, J. K. White, A. Bradley, P. Flicek, S. Wells, W. C. Skarnes, D. J. Adams, H. Parkinson, A. M. Mallon, S. D. M. Brown and D. Smedley (2017). "Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium." Nat Genet 49(8): 1231-1238. (co-authored by TCP staff)

Mishra, N., P. Wang, D. Goldsmith, X. Zhao, Y. Xue, U. Christians and B. A. Minassian (2017). "Everolimus does not prevent Lafora body formation in murine Lafora disease." Neurol Genet 3(1): e127.

Moffitt, A. B., S. L. Ondrejka, M. McKinney, R. E. Rempel, J. R. Goodlad, C. H. Teh, S. Leppa, S. Mannisto, P. E. Kovanen, E. Tse, R. K. H. Au-Yeung, Y. L. Kwong, G. Srivastava, J. Iqbal, J. Yu, K. Naresh, D. Villa, R. D. Gascoyne, J. Said, M. B. Czader, A. Chadburn, K. L. Richards, D. Rajagopalan, N. S. Davis, E. C. Smith, B. C. Palus, T. J. Tzeng, J. A. Healy, P. L. Lugar, J. Datta, C. Love, S. Levy, D. B. Dunson, Y. Zhuang, E. D. Hsi and S. S. Dave (2017). "Enteropathy-associated T cell lymphoma subtypes are characterized by loss of function of SETD2." J Exp Med 214(5): 1371-1386.

Nitschke, F., M. A. Sullivan, P. Wang, X. Zhao, E. E. Chown, A. M. Perri, L. Israelian, L. Juana-Lopez, P. Bovolenta, S. Rodriguez de Cordoba, M. Steup and B. A. Minassian (2017). "Abnormal glycogen chain length pattern, not hyperphosphorylation, is critical in Lafora disease." EMBO Mol Med 9(7): 906-917.

Nosi, U., F. Lanner, T. Huang and B. Cox (2017). "Overexpression of Trophoblast Stem Cell-Enriched MicroRNAs Promotes Trophoblast Fate in Embryonic Stem Cells." Cell Rep 19(6): 1101-1109.

Oh, E., R. Jeremian, G. Oh, D. Groot, M. Susic, K. Lee, K. Foy, P. W. Laird, A. Petronis and V. Labrie (2017). "Transcriptional heterogeneity in the lactase gene within cell-type is linked to the epigenome." Sci Rep 7: 41843.

Panaro, B. L., G. B. Flock, J. E. Campbell, J. L. Beaudry, X. Cao and D. J. Drucker (2017). "beta-Cell Inactivation of Gpr119 Unmasks Incretin Dependence of GPR119-Mediated Glucoregulation." Diabetes 66(6): 1626-1635.

Petrosova, H., A. Eshghi, Z. Anjum, N. Zlotnikov, C. E. Cameron and T. J. Moriarty (2017). "Diet-Induced Obesity Does Not Alter Tigecycline Treatment Efficacy in Murine Lyme Disease." Front Microbiol 8: 292.

Portnoy, S., M. Seed, J. G. Sled and C. K. Macgowan (2017). "Non-invasive evaluation of blood oxygen saturation and hematocrit from T1 and T2 relaxation times: In-vitro validation in fetal blood." Magn Reson Med. (co-authored by Mouse Imaging Centre staff)

Posfai, E., S. Petropoulos, F. R. de Barros, J. P. Schell, I. Jurisica, R. Sandberg, F. Lanner and J. Rossant (2017). "Position- and Hippo signaling-dependent plasticity during lineage segregation in the early mouse embryo." Elife 6.

Rahman, A., L. S. Cahill, Y. Q. Zhou, J. Hoggarth, M. Y. Rennie, M. Seed, C. K. Macgowan, J. C. Kingdom, S. L. Adamson and J. G. Sled (2017). "A mouse model of antepartum stillbirth." Am J Obstet Gynecol. (co-authored by Mouse Imaging Centre staff)

Rahman, A., Y. Q. Zhou, Y. Yee, J. Dazai, L. S. Cahill, J. Kingdom, C. K. Macgowan and J. G. Sled (2017). "Ultrasound detection of altered placental vascular morphology based on hemodynamic pulse wave reflection." Am J Physiol Heart Circ Physiol 312(5): H1021-H1029. (co-authored by Mouse Imaging Centre staff)

Salehi, S., X. Wang, S. Juvet, J. A. Scott and C. W. Chow (2017). "Syk Regulates Neutrophilic Airway Hyper-Responsiveness in a Chronic Mouse Model of Allergic Airways Inflammation." PLoS One 12(1): e0163614.

Sambi, M., T. Chow, J. Whiteley, M. Li, S. Chua, V. Raileanu and I. M. Rogers (2017). "Acellular Mouse Kidney ECM can be Used as a Three-Dimensional Substrate to Test the Differentiation Potential of Embryonic Stem Cell Derived Renal Progenitors." Stem Cell Rev 13(4): 513-531.

Sarswat, A., E. Wasilewski, S. K. Chakka, A. M. Bello, A. V. Caprariello, C. M. Muthuramu, P. K. Stys, S. E. Dunn and L. P. Kotra (2017). "Inhibitors of protein arginine deiminases and their efficacy in animal models of multiple sclerosis." Bioorg Med Chem 25(9): 2643-2656.

Shlush, E., L. Maghen, S. Swanson, S. Kenigsberg, S. Moskovtsev, T. Barretto, A. Gauthier-Fisher and C. L. Librach (2017). "In vitro generation of Sertoli-like and haploid spermatid-like cells from human umbilical cord perivascular cells." Stem Cell Res Ther 8(1): 37.

Singha, S., K. Shao, Y. Yang, X. Clemente-Casares, P. Sole, A. Clemente, J. Blanco, Q. Dai, F. Song, S. W. Liu, J. Yamanouchi, C. S. Umeshappa, R. H. Nanjundappa, P. Detampel, M. Amrein, C. Fandos, R. Tanguay, S. Newbigging, P. Serra, A. Khadra, W. C. W. Chan and P. Santamaria (2017). "Peptide-MHC-based nanomedicines for autoimmunity function as T-cell receptor microclustering devices." Nat Nanotechnol 12(7): 701-710. (co-authored by TCP staff)

Sundberg, J. P., S. S. Dadras, K. A. Silva, V. E. Kennedy, G. Garland, S. A. Murray, B. A. Sundberg, P. N. Schofield and C. H. Pratt (2017). "Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program." PLoS One 12(7): e0180682.

Tang, T. T., L. Zhang, A. Bansal, M. Grynpas and T. J. Moriarty (2017). "The Lyme Disease Pathogen Borrelia burgdorferi Infects Murine Bone and Induces Trabecular Bone Loss." Infect Immun 85(2).

Wang, A., L. R. Carraro-Lacroix, C. Owen, B. Gao, P. N. Corey, P. Tyrrell, J. H. Brumell and I. Voronov (2017). "Activity-independent targeting of mTOR to lysosomes in primary osteoclasts." Sci Rep 7(1): 3005. (co-authored by TCP staff)

Willett, T., D. Josey, R. X. Z. Lu, G. Minhas and J. Montesano (2017). "The micro-damage process zone during transverse cortical bone fracture: No ears at crack growth initiation." J Mech Behav Biomed Mater 74: 371-382.

Wismann, P., P. Barkholt, T. Secher, N. Vrang, H. B. Hansen, P. B. Jeppesen, L. L. Baggio, J. A. Koehler, D. J. Drucker, D. A. Sandoval and J. Jelsing (2017). "The endogenous preproglucagon system is not essential for gut growth homeostasis in mice." Mol Metab 6(7): 681-692.

Woolman, M., A. Gribble, E. Bluemke, J. Zou, M. Ventura, N. Bernards, M. Wu, H. J. Ginsberg, S. Das, A. Vitkin and A. Zarrine-Afsar (2017). "Optimized Mass Spectrometry Analysis Workflow with Polarimetric Guidance for ex vivo and in situ Sampling of Biological Tissues." Sci Rep 7(1): 468.

Yin, J. C., M. J. Platt, X. Tian, X. Wu, P. H. Backx, J. A. Simpson, T. Araki and B. G. Neel (2017). "Cellular interplay via cytokine hierarchy causes pathological cardiac hypertrophy in RAF1-mutant Noonan syndrome." Nat Commun 8: 15518.

Yusta, B., D. Matthews, G. B. Flock, J. R. Ussher, B. Lavoie, G. M. Mawe and D. J. Drucker (2017). "Glucagon-like peptide-2 promotes gallbladder refilling via a TGR5-independent, GLP-2R-dependent pathway." Mol Metab 6(6): 503-511.

Zhang, L., K. S. Sugamori, C. Claridge, A. Dela Cruz, M. D. Grynpas and J. Mitchell (2017). "Overexpression of GalphaS in Murine Osteoblasts In Vivo Leads to Increased Bone Mass and Decreased Bone Quality." J Bone Miner Res.

2016

Abbassi, L., S. Malki, K. Cockburn, A. Macaulay, C. Robert, J. Rossant and H. J. Clarke (2016). "Multiple Mechanisms Cooperate to Constitutively Exclude the Transcriptional Co-Activator YAP from the Nucleus During Murine Oogenesis." Biol Reprod 94(5): 102.

Akbar, N., B. Banwell, J. G. Sled, M. A. Binns, S. M. Doesburg, B. Rypma, M. Lysenko and C. Till (2016). "Brain activation patterns and cognitive processing speed in patients with pediatric-onset multiple sclerosis." J Clin Exp Neuropsychol 38(4): 393-403. (co-authored by Mouse Imaging Centre staff)

Akbar, N., A. Giorgio, C. Till, J. G. Sled, S. M. Doesburg, N. De Stefano and B. Banwell (2016). "Alterations in Functional and Structural Connectivity in Pediatric-Onset Multiple Sclerosis." PLoS One 11(1): e0145906. (co-authored by Mouse Imaging Centre staff)

Akbar, N., C. Till, J. G. Sled, M. A. Binns, S. M. Doesburg, B. Aubert-Broche, D. L. Collins, D. Araujo, S. Narayanan, D. L. Arnold, M. Lysenko and B. Banwell (2016). "Altered resting-state functional connectivity in cognitively preserved pediatric-onset MS patients and relationship to structural damage and cognitive performance." Mult Scler 22(6): 792-800. (co-authored by Mouse Imaging Centre staff)

Ali, S. A., M. Al-Jazrawe, H. Ma, H. Whetstone, R. Poon, S. Farr, M. Naples, K. Adeli and B. A. Alman (2016). "Regulation of Cholesterol Homeostasis by Hedgehog Signaling in Osteoarthritic Cartilage." Arthritis Rheumatol 68(1): 127-137.

Ameis, S. H., J. P. Lerch, M. J. Taylor, W. Lee, J. D. Viviano, J. Pipitone, A. Nazeri, P. E. Croarkin, A. N. Voineskos, M. C. Lai, J. Crosbie, J. Brian, N. Soreni, R. Schachar, P. Szatmari, P. D. Arnold and E. Anagnostou (2016). "A Diffusion Tensor Imaging Study in Children With ADHD, Autism Spectrum Disorder, OCD, and Matched Controls: Distinct and Non-Distinct White Matter Disruption and Dimensional Brain-Behavior Relationships." Am J Psychiatry: appiajp201615111435. (co-authored by Mouse Imaging Centre staff)

Anacker, C., J. Scholz, K. J. O'Donnell, R. Allemang-Grand, J. Diorio, R. C. Bagot, E. J. Nestler, R. Hen, J. P. Lerch and M. J. Meaney (2016). "Neuroanatomic Differences Associated With Stress Susceptibility and Resilience." Biol Psychiatry 79(10): 840-849. (co-authored by Mouse Imaging Centre staff)

Bartczak, A., A. Chruscinski, M. Mendicino, H. Liu, J. Zhang, W. He, A. Z. Amir, A. Nguyen, R. Khattar, H. Sadozai, C. G. Lobe, O. Adeyi, M. J. Phillips, L. Zhang, R. M. Gorczynski, D. Grant and G. A. Levy (2016). "Overexpression of Fibrinogen-Like Protein 2 Promotes Tolerance in a Fully Mismatched Murine Model of Heart Transplantation." Am J Transplant 16(6): 1739-1750.

Batchu, S. N., S. Majumder, B. B. Bowskill, K. E. White, S. L. Advani, A. S. Brijmohan, Y. Liu, K. Thai, P. M. Azizi, W. L. Lee and A. Advani (2016). "Prostaglandin I2 Receptor Agonism Preserves beta-Cell Function and Attenuates Albuminuria Through Nephrin-Dependent Mechanisms." Diabetes 65(5): 1398-1409.

Belinson, H., J. Nakatani, B. A. Babineau, R. Y. Birnbaum, J. Ellegood, M. Bershteyn, R. J. McEvilly, J. M. Long, K. Willert, O. D. Klein, N. Ahituv, J. P. Lerch, M. G. Rosenfeld and A. Wynshaw-Boris (2016). "Prenatal beta-catenin/Brn2/Tbr2 transcriptional cascade regulates adult social and stereotypic behaviors." Mol Psychiatry 21(10): 1417-1433. (co-authored by Mouse Imaging Centre staff)

Blake, J., D. Hu, J. E. Cain and N. D. Rosenblum (2016). "Urogenital development in Pallister-Hall syndrome is disrupted in a cell-lineage-specific manner by constitutive expression of GLI3 repressor." Hum Mol Genet 25(3): 437-447.

Boivin, F. J., S. Sarin, P. Dabas, M. Karolak, L. Oxburgh and D. Bridgewater (2016). "Stromal beta-catenin overexpression contributes to the pathogenesis of renal dysplasia." J Pathol 239(2): 174-185.

Bulut-Karslioglu, A., S. Biechele, H. Jin, T. A. Macrae, M. Hejna, M. Gertsenstein, J. S. Song and M. Ramalho-Santos (2016). "Inhibition of mTOR induces a paused pluripotent state." Nature. (co-authored by TCP staff)

Cahill, L. S., L. M. Gazdzinski, A. K. Tsui, Y. Q. Zhou, S. Portnoy, E. Liu, C. D. Mazer, G. M. Hare, A. Kassner and J. G. Sled (2016). "Functional and anatomical evidence of cerebral tissue hypoxia in young sickle cell anemia mice." J Cereb Blood Flow Metab. (co-authored by Mouse Imaging Centre staff)

Campbell, J. E., J. R. Ussher, E. E. Mulvihill, J. Kolic, L. L. Baggio, X. Cao, Y. Liu, B. J. Lamont, T. Morii, C. J. Streutker, N. Tamarina, L. H. Philipson, J. L. Wrana, P. E. MacDonald and D. J. Drucker (2016). "TCF1 links GIPR signaling to the control of beta cell function and survival." Nat Med 22(1): 84-90.

Chakravarty, M. M., C. Hamani, A. Martinez-Canabal, J. Ellegood, C. Laliberte, J. N. Nobrega, T. Sankar, A. M. Lozano, P. W. Frankland and J. P. Lerch (2016). "Deep brain stimulation of the ventromedial prefrontal cortex causes reorganization of neuronal processes and vasculature." Neuroimage 125: 422-427. (co-authored by Mouse Imaging Centre staff)

Chen, Z., K. Yu, F. Zhu and R. Gorczynski (2016). "Over-Expression of CD200 Protects Mice from Dextran Sodium Sulfate Induced Colitis." PLoS One 11(2): e0146681.

Civitarese, R. A., I. Talior-Volodarsky, J. F. Desjardins, G. Kabir, J. Switzer, M. Mitchell, A. Kapus, C. A. McCulloch, D. Gullberg and K. A. Connelly (2016). "The alpha11 integrin mediates fibroblast-extracellular matrix-cardiomyocyte interactions in health and disease." Am J Physiol Heart Circ Physiol 311(1): H96-H106.

Cohen, J. (2016). "Mice made easy." Science 354(6312): 538-542.

Corre, C., M. Friedel, D. A. Vousden, A. Metcalf, S. Spring, L. R. Qiu, J. P. Lerch and M. R. Palmert (2016). "Separate effects of sex hormones and sex chromosomes on brain structure and function revealed by high-resolution magnetic resonance imaging and spatial navigation assessment of the Four Core Genotype mouse model." Brain Struct Funct 221(2): 997-1016. (co-authored by Mouse Imaging Centre staff)

Corre, C., G. Shinoda, H. Zhu, D. L. Cousminer, C. Crossman, C. Bellissimo, A. Goldenberg, G. Q. Daley and M. R. Palmert (2016). "Sex-specific regulation of weight and puberty by the Lin28/let-7 axis." J Endocrinol 228(3): 179-191.

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Sharda, M., N. E. Foster, A. Tryfon, K. A. Doyle-Thomas, T. Ouimet, E. Anagnostou, A. C. Evans, L. Zwaigenbaum, J. P. Lerch, J. D. Lewis, K. L. Hyde and A. S. D. I. G. for NeuroDevNet (2016). "Language Ability Predicts Cortical Structure and Covariance in Boys with Autism Spectrum Disorder." Cereb Cortex. (co-authored by Mouse Imaging Centre staff)

Shaw, P., D. Weingart, T. Bonner, B. Watson, M. T. Park, W. Sharp, J. P. Lerch and M. M. Chakravarty (2016). "Defining the neuroanatomic basis of motor coordination in children and its relationship with symptoms of attention-deficit/hyperactivity disorder." Psychol Med 46(11): 2363-2373. (co-authored by Mouse Imaging Centre staff)

Sima, C., G. M. Aboodi, F. S. Lakschevitz, C. Sun, M. B. Goldberg and M. Glogauer (2016). "Nuclear Factor Erythroid 2-Related Factor 2 Down-Regulation in Oral Neutrophils Is Associated with Periodontal Oxidative Damage and Severe Chronic Periodontitis." Am J Pathol 186(6): 1417-1426.

Smeeton, J., P. Dhir, D. Hu, M. M. Feeney, L. Chen and N. D. Rosenblum (2016). "Integrin-linked Kinase Controls Renal Branching Morphogenesis via Dual Specificity Phosphatase 8." J Am Soc Nephrol 27(5): 1465-1477.

Smiley, S., P. E. Nickerson, L. Comanita, N. Daftarian, A. El-Sehemy, E. L. Tsai, S. Matan-Lithwick, K. Yan, S. Thurig, Y. Touahri, R. Dixit, T. Aavani, Y. De Repentingy, A. Baker, C. Tsilfidis, J. Biernaskie, Y. Sauve, C. Schuurmans, R. Kothary, A. J. Mears and V. A. Wallace (2016). "Establishment of a cone photoreceptor transplantation platform based on a novel cone-GFP reporter mouse line." Sci Rep 6: 22867.

Solomon, H. M., S. L. Makris, H. Alsaid, O. Bermudez, B. K. Beyer, A. Chen, C. L. Chen, Z. Chen, G. Chmielewski, A. M. DeLise, L. de Schaepdrijver, B. Dogdas, J. French, W. Harrouk, J. Helfgott, R. M. Henkelman, J. Hesterman, K. W. Hew, A. Hoberman, C. W. Lo, A. McDougal, D. R. Minck, L. Scott, J. Stewart, V. Sutherland, A. K. Tatiparthi, C. T. Winkelmann, L. D. Wise, S. L. Wood and X. Ying (2016). "Micro-CT imaging: Developing criteria for examining fetal skeletons in regulatory developmental toxicology studies - A workshop report." Regul Toxicol Pharmacol 77: 100-108. (co-authored by Mouse Imaging Centre staff)

Souma, T., S. W. Tompson, B. R. Thomson, O. M. Siggs, K. Kizhatil, S. Yamaguchi, L. Feng, V. Limviphuvadh, K. N. Whisenhunt, S. Maurer-Stroh, T. L. Yanovitch, L. Kalaydjieva, D. N. Azmanov, S. Finzi, L. Mauri, S. Javadiyan, E. Souzeau, T. Zhou, A. W. Hewitt, B. Kloss, K. P. Burdon, D. A. Mackey, K. F. Allen, J. B. Ruddle, S. H. Lim, S. Rozen, K. N. Tran-Viet, X. Liu, S. John, J. L. Wiggs, F. Pasutto, J. E. Craig, J. Jin, S. E. Quaggin and T. L. Young (2016). "Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity." J Clin Invest 126(7): 2575-2587.

Sussman, D., R. C. Leung, M. M. Chakravarty, J. P. Lerch and M. J. Taylor (2016). "Developing human brain: age-related changes in cortical, subcortical, and cerebellar anatomy." Brain Behav 6(4): e00457. (co-authored by Mouse Imaging Centre staff)

Tang, T. T., L. Zhang, A. Bansal, M. Grynpas and T. J. Moriarty (2016). "The Lyme disease pathogen Borrelia burgdorferi infects murine bone and induces trabecular bone loss." Infect Immun.

Tattoli, I., S. A. Killackey, E. G. Foerster, R. Molinaro, C. Maisonneuve, M. A. Rahman, S. Winer, D. A. Winer, C. J. Streutker, D. J. Philpott and S. E. Girardin (2016). "NLRX1 Acts as an Epithelial-Intrinsic Tumor Suppressor through the Modulation of TNF-Mediated Proliferation." Cell Rep 14(11): 2576-2586.

Tkac, J., G. Xu, H. Adhikary, J. T. Young, D. Gallo, C. Escribano-Diaz, J. Krietsch, A. Orthwein, M. Munro, W. Sol, A. Al-Hakim, Z. Y. Lin, J. Jonkers, P. Borst, G. W. Brown, A. C. Gingras, S. Rottenberg, J. Y. Masson and D. Durocher (2016). "HELB Is a Feedback Inhibitor of DNA End Resection." Mol Cell 61(3): 405-418.

Torchia, J., B. Golbourn, S. Feng, K. C. Ho, P. Sin-Chan, A. Vasiljevic, J. D. Norman, P. Guilhamon, L. Garzia, N. R. Agamez, M. Lu, T. S. Chan, D. Picard, P. de Antonellis, D. A. Khuong-Quang, A. C. Planello, C. Zeller, D. Barsyte-Lovejoy, L. Lafay-Cousin, L. Letourneau, M. Bourgey, M. Yu, D. M. Gendoo, M. Dzamba, M. Barszczyk, T. Medina, A. N. Riemenschneider, A. S. Morrissy, Y. S. Ra, V. Ramaswamy, M. Remke, C. P. Dunham, S. Yip, H. K. Ng, J. Q. Lu, V. Mehta, S. Albrecht, J. Pimentel, J. A. Chan, G. R. Somers, C. C. Faria, L. Roque, M. Fouladi, L. M. Hoffman, A. S. Moore, Y. Wang, S. A. Choi, J. R. Hansford, D. Catchpoole, D. K. Birks, N. K. Foreman, D. Strother, A. Klekner, L. Bognar, M. Garami, P. Hauser, T. Hortobagyi, B. Wilson, J. Hukin, A. S. Carret, T. E. Van Meter, E. I. Hwang, A. Gajjar, S. H. Chiou, H. Nakamura, H. Toledano, I. Fried, D. Fults, T. Wataya, C. Fryer, D. D. Eisenstat, K. Scheinemann, A. J. Fleming, D. L. Johnston, J. Michaud, S. Zelcer, R. Hammond, S. Afzal, D. A. Ramsay, N. Sirachainan, S. Hongeng, N. Larbcharoensub, R. G. Grundy, R. R. Lulla, J. R. Fangusaro, H. Druker, U. Bartels, R. Grant, D. Malkin, C. J. McGlade, T. Nicolaides, T. Tihan, J. Phillips, J. Majewski, A. Montpetit, G. Bourque, G. D. Bader, A. T. Reddy, G. Y. Gillespie, M. Warmuth-Metz, S. Rutkowski, U. Tabori, M. Lupien, M. Brudno, U. Schuller, T. Pietsch, A. R. Judkins, C. E. Hawkins, E. Bouffet, S. K. Kim, P. B. Dirks, M. D. Taylor, A. Erdreich-Epstein, C. H. Arrowsmith, D. D. De Carvalho, J. T. Rutka, N. Jabado and A. Huang (2016). "Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors." Cancer Cell 30(6): 891-908.

Tran, V., S. K. Ahn, M. Ng, M. Li and J. Liu (2016). "Loss of Lipid Virulence Factors Reduces the Efficacy of the BCG Vaccine." Sci Rep 6: 29076.

Vincent, R. D., P. Neelin, N. Khalili-Mahani, A. L. Janke, V. S. Fonov, S. M. Robbins, L. Baghdadi, J. Lerch, J. G. Sled, R. Adalat, D. MacDonald, A. P. Zijdenbos, D. L. Collins and A. C. Evans (2016). "MINC 2.0: A Flexible Format for Multi-Modal Images." Front Neuroinform 10: 35. (co-authored by Mouse Imaging Centre staff)

Wu, A. M., L. Dedina, P. Dalvi, M. Yang, J. Leon-Cheon, B. Earl, P. A. Harper and S. Ito (2016). "Riboflavin uptake transporter Slc52a2 (RFVT2) is upregulated in the mouse mammary gland during lactation." Am J Physiol Regul Integr Comp Physiol 310(7): R578-585.

Xiao, J., S. R. Vemula, Y. Xue, M. M. Khan, F. A. Carlisle, A. J. Waite, D. J. Blake, I. Dragatsis, Y. Zhao and M. S. LeDoux (2016). "Role of major and brain-specific Sgce isoforms in the pathogenesis of myoclonus-dystonia syndrome." Neurobiol Dis 98: 52-65.

Young, J. M., B. R. Morgan, H. E. Whyte, W. Lee, M. L. Smith, C. Raybaud, M. M. Shroff, J. G. Sled and M. J. Taylor (2016). "Longitudinal Study of White Matter Development and Outcomes in Children Born Very Preterm." Cereb Cortex. (co-authored by Mouse Imaging Centre staff)

Zaghlool, A., J. Halvardson, J. J. Zhao, M. Etemadikhah, A. Kalushkova, K. Konska, H. Jernberg-Wiklund, A. C. Thuresson and L. Feuk (2016). "A Role for the Chromatin-Remodeling Factor BAZ1A in Neurodevelopment." Hum Mutat 37(9): 964-975.

Zanello, G., A. Goethel, S. Rouquier, D. Prescott, S. J. Robertson, C. Maisonneuve, C. Streutker, D. J. Philpott and K. Croitoru (2016). "The Cytosolic Microbial Receptor Nod2 Regulates Small Intestinal Crypt Damage and Epithelial Regeneration following T Cell-Induced Enteropathy." J Immunol 197(1): 345-355.

Zhang, R. X., P. Cai, T. Zhang, K. Chen, J. Li, J. Cheng, K. S. Pang, H. A. Adissu, A. M. Rauth and X. Y. Wu (2016). "Polymer-lipid hybrid nanoparticles synchronize pharmacokinetics of co-encapsulated doxorubicin-mitomycin C and enable their spatiotemporal co-delivery and local bioavailability in breast tumor." Nanomedicine 12(5): 1279-1290. (co-authored by TCP staff)

Zhu, M. Y., N. Milligan, S. Keating, R. Windrim, J. Keunen, V. Thakur, A. Ohman, S. Portnoy, J. G. Sled, E. Kelly, S. J. Yoo, L. Gross-Wortmann, E. Jaeggi, C. K. Macgowan, J. C. Kingdom and M. Seed (2016). "The hemodynamics of late-onset intrauterine growth restriction by MRI." Am J Obstet Gynecol 214(3): 367 e361-367 e317. (co-authored by Mouse Imaging Centre staff)

Zlotnikov, N., A. Javid, M. Ahmed, A. Eshghi, T. T. Tang, A. Arya, A. Bansal, F. Matar, M. Parikh, R. Ebady, A. Koh, N. Gupta, P. Song, Y. Zhang, S. Newbigging, G. P. Wormser, I. Schwartz, R. Inman, M. Glogauer and T. J. Moriarty (2016). "Infection with the Lyme disease pathogen suppresses innate immunity in mice with diet-induced obesity." Cell Microbiol. (co-authored by TCP staff)

2015

Abraham, S., M. Scarcia, R. D. Bagshaw, K. McMahon, G. Grant, T. Harvey, M. Yeo, F. O. Esteves, H. H. Thygesen, P. F. Jones, V. Speirs, A. M. Hanby, P. J. Selby, M. Lorger, T. N. Dear, T. Pawson, C. J. Marshall and G. Mavria (2015). "A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis." Nat Commun 6: 7286.

Adissu, H. A., C. McKerlie, M. Di Grappa, P. Waterhouse, Q. Xu, H. Fang, R. Khokha and G. A. Wood (2015). "Timp3 loss accelerates tumour invasion and increases prostate inflammation in a mouse model of prostate cancer." Prostate. (co-authored by TCP staff)

Adissu, H. A., G. A. Medhanie, L. Morikawa, J. K. White, S. Newbigging and C. McKerlie (2015). "Right Ventricular Epicardial Fibrosis in Mice With Sternal Segment Dislocation." Vet Pathol 52(5): 967-976. (co-authored by TCP staff)

Akbar, N., B. Banwell, J. G. Sled, M. A. Binns, S. M. Doesburg, B. Rypma, M. Lysenko and C. Till (2015). "Brain activation patterns and cognitive processing speed in patients with pediatric-onset multiple sclerosis." J Clin Exp Neuropsychol: 1-11. (co-authored by Mouse Imaging Centre staff)

Akbar, N., C. Till, J. G. Sled, M. A. Binns, S. M. Doesburg, B. Aubert-Broche, D. L. Collins, D. Araujo, S. Narayanan, D. L. Arnold, M. Lysenko and B. Banwell (2015). "Altered resting-state functional connectivity in cognitively preserved pediatric-onset MS patients and relationship to structural damage and cognitive performance." Mult Scler. (co-authored by Mouse Imaging Centre staff)

Ali, S., J. R. Ussher, L. L. Baggio, M. G. Kabir, M. J. Charron, O. Ilkayeva, C. B. Newgard and D. J. Drucker (2015). "Cardiomyocyte glucagon receptor signaling modulates outcomes in mice with experimental myocardial infarction." Mol Metab 4(2): 132-143.

Ali, S. A., M. Al-Jazrawe, H. Ma, H. Whetstone, R. Poon, S. Farr, M. Naples, K. Adeli and B. Alman (2015). "Hedgehog signaling regulates cholesterol homeostasis in osteoarthritic cartilage." Arthritis Rheumatol.

Allemang-Grand, R., J. Scholz, J. Ellegood, L. S. Cahill, C. Laliberte, P. E. Fraser, S. A. Josselyn, J. G. Sled and J. P. Lerch (2015). "Altered brain development in an early-onset murine model of Alzheimer's disease." Neurobiol Aging 36(2): 638-647. (co-authored by Mouse Imaging Centre staff)

Amadei, G., M. A. Zander, G. Yang, J. G. Dumelie, J. P. Vessey, H. D. Lipshitz, C. A. Smibert, D. R. Kaplan and F. D. Miller (2015). "A Smaug2-Based Translational Repression Complex Determines the Balance between Precursor Maintenance versus Differentiation during Mammalian Neurogenesis." J Neurosci 35(47): 15666-15681.

Anacker, C., J. Scholz, K. J. O'Donnell, R. Allemang-Grand, J. Diorio, R. C. Bagot, E. J. Nestler, R. Hen, J. P. Lerch and M. J. Meaney (2015). "Neuroanatomic Differences Associated with Stress Susceptibility and Resilience." Biol Psychiatry. (co-authored by Mouse Imaging Centre staff)

Anderson, G. A., R. S. Udan, M. E. Dickinson and R. M. Henkelman (2015). "Cardiovascular Patterning as Determined by Hemodynamic Forces and Blood Vessel Genetics." PLoS One 10(9): e0137175. (co-authored by Mouse Imaging Centre staff)

Badouel, C., M. A. Zander, N. Liscio, M. Bagherie-Lachidan, R. Sopko, E. Coyaud, B. Raught, F. D. Miller and H. McNeill (2015). "Fat1 interacts with Fat4 to regulate neural tube closure, neural progenitor proliferation and apical constriction during mouse brain development." Development 142(16): 2781-2791.

Bae, E. H., A. Konvalinka, F. Fang, X. Zhou, V. Williams, N. Maksimowski, X. Song, S. L. Zhang, R. John, G. Y. Oudit, Y. Pei and J. W. Scholey (2015). "Characterization of the intrarenal renin-angiotensin system in experimental alport syndrome." Am J Pathol 185(5): 1423-1435.

Bagherie-Lachidan, M., A. Reginensi, Q. Pan, H. P. Zaveri, D. A. Scott, B. J. Blencowe, F. Helmbacher and H. McNeill (2015). "Stromal Fat4 acts non-autonomously with Dchs1/2 to restrict the nephron progenitor pool." Development 142(15): 2564-2573.

Baht, G. S., D. Silkstone, L. Vi, P. Nadesan, Y. Amani, H. Whetstone, Q. Wei and B. A. Alman (2015). "Exposure to a youthful circulaton rejuvenates bone repair through modulation of beta-catenin." Nat Commun 6: 7131.

Bartczak, A., A. Chruscinski, M. Mendicino, H. Liu, J. Zhang, W. He, A. Z. Amir, A. Nguyen, R. Khattar, H. Sadozai, C. G. Lobe, O. Adeyi, M. J. Phillips, L. Zhang, R. M. Gorczynski, D. Grant and G. A. Levy (2015). "Overexpression of Fibrinogen-Like Protein 2 Promotes Tolerance in a Fully Mismatched Murine Model of Heart Transplantation." Am J Transplant.

Benevento, M., P. D. Tonge, M. C. Puri, A. Nagy, A. J. Heck and J. Munoz (2015). "Fluctuations in histone H4 isoforms during cellular reprogramming monitored by middle-down proteomics." Proteomics.

Ben-Meir, A., E. Burstein, A. Borrego-Alvarez, J. Chong, E. Wong, T. Yavorska, T. Naranian, M. Chi, Y. Wang, Y. Bentov, J. Alexis, J. Meriano, H. K. Sung, D. L. Gasser, K. H. Moley, S. Hekimi, R. F. Casper and A. Jurisicova (2015). "Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging." Aging Cell 14(5): 887-895.

Blake, J., D. Hu, J. E. Cain and N. D. Rosenblum (2015). "Urogenital development in Pallister-Hall syndrome is disrupted in a cell-lineage-specific manner by constitutive expression of GLI3 repressor." Hum Mol Genet.

Bonsignore, L. A., J. G. Tooley, P. M. Van Hoose, E. Wang, A. Cheng, M. P. Cole and C. E. Schaner Tooley (2015). "NRMT1 knockout mice exhibit phenotypes associated with impaired DNA repair and premature aging." Mech Ageing Dev 146-148: 42-52.

Boyd, K. L., B. Bolon and D. I. Bounous (2015). Clinical Pathology Analysis in Developing Mice. Pathology of the Developing Mouse: A Systematic Approach: 175.

Bubela, T. and R. Cook-Deegan (2015). "Keeping score, strengthening policy and fighting bad actors over access to research tools." Nat Biotechnol 33(2): 143-147.

Bubela, T., J. Guebert and A. Mishra (2015). "Use and misuse of material transfer agreements: lessons in proportionality from research, repositories, and litigation." PLoS Biol 13(2): e1002060.

Bubela, T., S. Vishnubhakat and R. Cook-Deegan (2015). "The mouse that trolled: the long and tortuous history of a gene mutation patent that became an expensive impediment to Alzheimer's research." Journal of Law and the Biosciences.

Cahill, L. S., P. E. Steadman, C. E. Jones, C. L. Laliberte, J. Dazai, J. P. Lerch, B. Stefanovic and J. G. Sled (2015). "MRI-detectable changes in mouse brain structure induced by voluntary exercise." Neuroimage 113: 175-183. (co-authored by Mouse Imaging Centre staff)

Chen, Y., M. A. Di Grappa, S. D. Molyneux, T. D. McKee, P. Waterhouse, J. M. Penninger and R. Khokha (2015). "RANKL blockade prevents and treats aggressive osteosarcomas." Sci Transl Med 7(317): 317ra197.

Consortium, I. (2015). "INFRAFRONTIER--providing mutant mouse resources as research tools for the international scientific community." Nucleic Acids Res 43(Database issue): D1171-1175.

Corre, C., G. Shinoda, H. Zhu, D. L. Cousminer, C. Crossman, C. Bellissimo, A. Goldenberg, G. Q. Daley and M. R. Palmert (2015). "Sex-specific regulation of weight and puberty by the Lin28/let-7 axis." J Endocrinol.

Dai, F. F., A. Bhattacharjee, Y. Liu, B. Batchuluun, M. Zhang, X. S. Wang, X. Huang, L. Luu, D. Zhu, H. Gaisano and M. B. Wheeler (2015). "A Novel GLP1 Receptor Interacting Protein ATP6ap2 Regulates Insulin Secretion in Pancreatic Beta Cells." J Biol Chem 290(41): 25045-25061.

de Angelis, M. H., G. Nicholson, M. Selloum, J. K. White, H. Morgan, R. Ramirez-Solis, T. Sorg, S. Wells, H. Fuchs, M. Fray, D. J. Adams, N. C. Adams, T. Adler, A. Aguilar-Pimentel, D. Ali-Hadji, G. Amann, P. Andre, S. Atkins, A. Auburtin, A. Ayadi, J. Becker, L. Becker, E. Bedu, R. Bekeredjian, M. C. Birling, A. Blake, J. Bottomley, M. R. Bowl, V. Brault, D. H. Busch, J. N. Bussell, J. Calzada-Wack, H. Cater, M. F. Champy, P. Charles, C. Chevalier, F. Chiani, G. F. Codner, R. Combe, R. Cox, E. Dalloneau, A. Dierich, A. Di Fenza, B. Doe, A. Duchon, O. Eickelberg, C. T. Esapa, L. E. Fertak, T. Feigel, I. Emelyanova, J. Estabel, J. Favor, A. Flenniken, A. Gambadoro, L. Garrett, H. Gates, A. K. Gerdin, G. Gkoutos, S. Greenaway, L. Glasl, P. Goetz, I. G. Da Cruz, A. Gotz, J. Graw, A. Guimond, W. Hans, G. Hicks, S. M. Holter, H. Hofler, J. M. Hancock, R. Hoehndorf, T. Hough, R. Houghton, A. Hurt, B. Ivandic, H. Jacobs, S. Jacquot, N. Jones, N. A. Karp, H. A. Katus, S. Kitchen, T. Klein-Rodewald, M. Klingenspor, T. Klopstock, V. Lalanne, S. Leblanc, C. Lengger, E. le Marchand, T. Ludwig, A. Lux, C. McKerlie, H. Maier, J. L. Mandel, S. Marschall, M. Mark, D. G. Melvin, H. Meziane, K. Micklich, C. Mittelhauser, L. Monassier, D. Moulaert, S. Muller, B. Naton, F. Neff, P. M. Nolan, L. M. Nutter, M. Ollert, G. Pavlovic, N. S. Pellegata, E. Peter, B. Petit-Demouliere, A. Pickard, C. Podrini, P. Potter, L. Pouilly, O. Puk, D. Richardson, S. Rousseau, L. Quintanilla-Fend, M. M. Quwailid, I. Racz, B. Rathkolb, F. Riet, J. Rossant, M. Roux, J. Rozman, E. Ryder, J. Salisbury, L. Santos, K. H. Schable, E. Schiller, A. Schrewe, H. Schulz, R. Steinkamp, M. Simon, M. Stewart, C. Stoger, T. Stoger, M. Sun, D. Sunter, L. Teboul, I. Tilly, G. P. Tocchini-Valentini, M. Tost, I. Treise, L. Vasseur, E. Velot, D. Vogt-Weisenhorn, C. Wagner, A. Walling, M. Wattenhofer-Donze, B. Weber, O. Wendling, H. Westerberg, M. Willershauser, E. Wolf, A. Wolter, J. Wood, W. Wurst, A. O. Yildirim, R. Zeh, A. Zimmer, A. Zimprich, E. Consortium, C. Holmes, K. P. Steel, Y. Herault, V. Gailus-Durner, A. M. Mallon and S. D. Brown (2015). "Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics." Nat Genet 47(9): 969-978. (co-authored by TCP staff)

de Guzman, A. E., L. M. Gazdzinski, R. J. Alsop, J. M. Stewart, D. A. Jaffray, C. S. Wong and B. J. Nieman (2015). "Treatment age, dose and sex determine neuroanatomical outcome in irradiated juvenile mice." Radiat Res 183(5): 541-549. (co-authored by Mouse Imaging Centre staff)

Dembowy, J., H. A. Adissu, J. C. Liu, E. Zacksenhaus and J. R. Woodgett (2015). "Effect of glycogen synthase kinase-3 inactivation on mouse mammary gland development and oncogenesis." Oncogene 34(27): 3514-3526. (co-authored by TCP staff)

Dworski, S., A. Berger, C. Furlonger, J. M. Moreau, M. Yoshimitsu, J. Trentadue, B. C. Au, C. J. Paige and J. A. Medin (2015). "Markedly perturbed hematopoiesis in acid ceramidase deficient mice." Haematologica 100(5): e162-165.

Ellegood, J., E. Anagnostou, B. A. Babineau, J. N. Crawley, L. Lin, M. Genestine, E. DiCicco-Bloom, J. K. Lai, J. A. Foster, O. Penagarikano, D. H. Geschwind, L. K. Pacey, D. R. Hampson, C. L. Laliberte, A. A. Mills, E. Tam, L. R. Osborne, M. Kouser, F. Espinosa-Becerra, Z. Xuan, C. M. Powell, A. Raznahan, D. M. Robins, N. Nakai, J. Nakatani, T. Takumi, M. C. van Eede, T. M. Kerr, C. Muller, R. D. Blakely, J. Veenstra-VanderWeele, R. M. Henkelman and J. P. Lerch (2015). "3D visualization of the regional differences." Mol Psychiatry 20(1): 1. (co-authored by Mouse Imaging Centre staff)

Ellegood, J., E. Anagnostou, B. A. Babineau, J. N. Crawley, L. Lin, M. Genestine, E. DiCicco-Bloom, J. K. Lai, J. A. Foster, O. Penagarikano, D. H. Geschwind, L. K. Pacey, D. R. Hampson, C. L. Laliberte, A. A. Mills, E. Tam, L. R. Osborne, M. Kouser, F. Espinosa-Becerra, Z. Xuan, C. M. Powell, A. Raznahan, D. M. Robins, N. Nakai, J. Nakatani, T. Takumi, M. C. van Eede, T. M. Kerr, C. Muller, R. D. Blakely, J. Veenstra-VanderWeele, R. M. Henkelman and J. P. Lerch (2015). "Clustering autism: using neuroanatomical differences in 26 mouse models to gain insight into the heterogeneity." Mol Psychiatry 20(1): 118-125. (co-authored by Mouse Imaging Centre staff)

Ellegood, J. and J. N. Crawley (2015). "Behavioral and Neuroanatomical Phenotypes in Mouse Models of Autism." Neurotherapeutics 12(3): 521-533. (co-authored by Mouse Imaging Centre staff)

Ellegood, J., N. Nakai, J. Nakatani, M. Henkelman, T. Takumi and J. Lerch (2015). "Neuroanatomical Phenotypes Are Consistent With Autism-Like Behavioral Phenotypes in the 15q11-13 Duplication Mouse Model." Autism Res. (co-authored by Mouse Imaging Centre staff)

Eppig, J. T., J. E. Richardson, J. A. Kadin, M. Ringwald, J. A. Blake and C. J. Bult (2015). "Mouse Genome Informatics (MGI): reflecting on 25 years." Mamm Genome 26(7-8): 272-284.

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Zappitelli, T., F. Chen and J. E. Aubin (2015). "Up-regulation of BMP2/4 signaling increases both osteoblast-specific marker expression and bone marrow adipogenesis in Gja1Jrt/+ stromal cell cultures." Mol Biol Cell 26(5): 832-842.

Zhang, R., Y. Pan, V. Fanelli, S. Wu, A. A. Luo, D. Islam, B. Han, P. Mao, M. Ghazarian, W. Zeng, P. M. Spieth, D. Wang, J. Khang, H. Mo, X. Liu, S. Uhlig, M. Liu, J. Laffey, A. S. Slutsky, Y. Li and H. Zhang (2015). "Mechanical Stress and the Induction of Lung Fibrosis via the Midkine Signaling Pathway." Am J Respir Crit Care Med 192(3): 315-323.

Zhu, M. Y., N. Milligan, S. Keating, R. Windrim, J. Keunen, V. Thakur, A. Ohman, S. Portnoy, J. G. Sled, E. Kelly, S. J. Yoo, L. Gross-Wortmann, E. Jaeggi, C. K. Macgowan, J. C. Kingdom and M. Seed (2015). "The hemodynamics of late onset intrauterine growth restriction by MRI." Am J Obstet Gynecol. (co-authored by Mouse Imaging Centre staff)

2014

Adissu, H. A., J. D. Baird and G. A. Wood (2014). "A Case of Bilateral Auricular Chondritis in a Heifer." Case Reports in Veterinary Medicine 2014: 1-4. (co-authored by TCP staff)

Adissu, H. A., J. Estabel, D. Sunter, E. Tuck, Y. Hooks, D. M. Carragher, K. Clarke, N. A. Karp, P. Sanger Mouse Genetics, S. Newbigging, N. Jones, L. Morikawa, J. K. White and C. McKerlie (2014). "Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen." Dis Model Mech 7(5): 515-524. (co-authored by TCP staff)

Amini-Nik, S., E. Cambridge, W. Yu, A. Guo, H. Whetstone, P. Nadesan, R. Poon, B. Hinz and B. A. Alman (2014). "beta-Catenin-regulated myeloid cell adhesion and migration determine wound healing." J Clin Invest 124(6): 2599-2610.

Baht, G. S., D. Silkstone, P. Nadesan, H. Whetstone and B. A. Alman (2014). "Activation of hedgehog signaling during fracture repair enhances osteoblastic-dependent matrix formation." J Orthop Res 32(4): 581-586.

Behringer, R., M. Gertsenstein, K. V. Nagy and A. Nagy (2014). Manipulating the Mouse Embryo: A Laboratory Manual, Cold Spring Harbor Laboratory Press. (co-authored by TCP staff)

Bilodeau, M., S. Shojaie, C. Ackerley, M. Post and J. Rossant (2014). "Identification of a proximal progenitor population from murine fetal lungs with clonogenic and multilineage differentiation potential." Stem Cell Reports 3(4): 634-649. (co-authored by TCP staff)

Brayton, C. F., C. McKerlie and S. Brown (2014). Analysis of Phenotype. Transgenic Animal Technology: A Laboratory Handbook: 431. (co-authored by TCP staff)

Brown, S. (2014). "Animal models: Mouse already being charted gene by gene." Nature 508(7496): 319-319. (co-authored by TCP staff)

Cahill, L. S., C. L. Laliberte, X. J. Liu, J. Bishop, B. J. Nieman, J. S. Mogil, R. E. Sorge, C. D. Jones, M. W. Salter and R. M. Henkelman (2014). "Quantifying blood-spinal cord barrier permeability after peripheral nerve injury in the living mouse." Mol Pain 10(1): 60. (co-authored by Mouse Imaging Centre staff)

Cardelli, M. and J. E. Aubin (2014). "ERRgamma is not required for skeletal development but is a RUNX2-dependent negative regulator of postnatal bone formation in male mice." PLoS One 9(10): e109592.

Chen, F., R. Guo, S. Itoh, L. Moreno, E. Rosenthal, T. Zappitelli, R. A. Zirngibl, A. Flenniken, W. Cole, M. Grynpas, L. R. Osborne, W. Vogel, L. Adamson, J. Rossant and J. E. Aubin (2014). "First mouse model for combined osteogenesis imperfecta and Ehlers-Danlos syndrome." J Bone Miner Res 29(6): 1412-1423. (co-authored by TCP staff)

Delgado-Olguin, P., L. T. Dang, D. He, S. Thomas, L. Chi, T. Sukonnik, N. Khyzha, M. W. Dobenecker, J. E. Fish and B. G. Bruneau (2014). "Ezh2-mediated repression of a transcriptional pathway upstream of Mmp9 maintains integrity of the developing vasculature." Development 141(23): 4610-4617.

Dib, S., S. Xiao, D. Miletic and J. Robertson (2014). "Gene targeting of mouse Tardbp negatively affects Masp2 expression." PLoS One 9(4): e95373.

Figueiredo, C. A., P. C. Drohomyrecky, S. D. McCarthy, D. Leontyev, X. Z. Ma, D. R. Branch and S. E. Dunn (2014). "Optimal attenuation of experimental autoimmune encephalomyelitis by intravenous immunoglobulin requires an intact interleukin-11 receptor." PLoS One 9(7): e101947.

Gertsenstein, M. (2014). “Tetraploid Complementation Assay.” The Guide to Investigation of Mouse Pregnancy: 107 & 489. (co-authored by TCP staff)

Hayes, M., X. Gao, L. X. Yu, N. Paria, R. M. Henkelman, C. A. Wise and B. Ciruna (2014). "ptk7 mutant zebrafish models of congenital and idiopathic scoliosis implicate dysregulated Wnt signalling in disease." Nat Commun 5: 4777. (co-authored by Mouse Imaging Centre staff)

Johnson, R. M., E. Papp, I. Grandal, P. E. Kowalski, L. Nutter, R. C. Wong, A. M. Joseph-George, J. S. Danska and C. J. Guidos (2014). "MuLV-related endogenous retroviral elements and Flt3 participate in aberrant end-joining events that promote B-cell leukemogenesis." Genes Dev 28(11): 1179-1190.

Johswich, A., C. Longuet, J. Pawling, A. Abdel Rahman, M. Ryczko, D. J. Drucker and J. W. Dennis (2014). "N-glycan remodeling on glucagon receptor is an effector of nutrient sensing by the hexosamine biosynthesis pathway." J Biol Chem 289(23): 15927-15941.

Kabaroff, L., A. Gupta, S. Menezes, Y. Babichev, R. C. Kandel, C. J. Swallow, B. C. Dickson and R. A. Gladdy (2014). "Development of genetically flexible mouse models of sarcoma using RCAS-TVA mediated gene delivery." PLoS One 9(4): e94817.

Kunath, T., Y. Yamanaka, J. Detmar, D. MacPhee, I. Caniggia, J. Rossant and A. Jurisicova (2014). "Developmental differences in the expression of FGF receptors between human and mouse embryos." Placenta 35(12): 1079-1088.

Li, H., D. Qu, A. McDonald, S. M. Isaac, K. J. Whiteley, H. K. Sung, A. Nagy and S. L. Adamson (2014). "Trophoblast-specific reduction of VEGFA alters placental gene expression and maternal cardiovascular function in mice." Biol Reprod 91(4): 87.

Liu, J., U. Deutsch, I. Fung and C. G. Lobe (2014). "Conditional and inducible transgene expression in endothelial and hematopoietic cells using Cre/ and tetracycline-off systems." Exp Ther Med 8(5): 1351-1356.

Michael, I. P., P. D. Westenskow, S. Hacibekiroglu, A. C. Greenwald, B. G. Ballios, T. Kurihara, Z. Li, C. M. Warren, P. Zhang, E. Aguilar, L. Donaldson, V. Marchetti, T. Baba, S. M. Hussein, H. K. Sung, M. L. Iruela-Arispe, J. M. Rini, D. van der Kooy, M. Friedlander and A. Nagy (2014). "Local acting Sticky-trap inhibits vascular endothelial growth factor dependent pathological angiogenesis in the eye." EMBO Mol Med 6(5): 604-623.

Mishra, A. and T. Bubela (2014). "Legal agreements and the governance of research commons: lessons from materials sharing in mouse genomics." OMICS 18(4): 254-273.

Perova, T., I. Grandal, L. M. Nutter, E. Papp, I. R. Matei, J. Beyene, P. E. Kowalski, J. K. Hitzler, M. D. Minden, C. J. Guidos and J. S. Danska (2014). "Therapeutic potential of spleen tyrosine kinase inhibition for treating high-risk precursor B cell acute lymphoblastic leukemia." Sci Transl Med 6(236): 236ra262.

Peter, M. R., M. Jerkic, V. Sotov, D. N. Douda, D. S. Ardelean, N. Ghamami, F. Lakschevitz, M. A. Khan, S. J. Robertson, M. Glogauer, D. J. Philpott, N. Palaniyar and M. Letarte (2014). "Impaired resolution of inflammation in the Endoglin heterozygous mouse model of chronic colitis." Mediators Inflamm 2014: 767185.

Pop, M., V. Ramanan, F. Yang, L. Zhang, S. Newbigging, N. R. Ghugre and G. A. Wright (2014). "High-resolution 3-D T1*-mapping and quantitative image analysis of GRAY ZONE in chronic fibrosis." IEEE Trans Biomed Eng 61(12): 2930-2938. (co-authored by TCP staff)

Pop, M., M. Sermesant, S. Oduneye, S. Ghate, L. Biswas, R. Flor, S. Newbigging, E. Crystal, N. Ayache and G. A. Wright (2014). Progress on Customization of Predictive MRI-Based Macroscopic Models from Experimental Data. Statistical Atlases and Computational Models of the Heart. Imaging and Modelling Challenges, Springer: 152-161. (co-authored by TCP staff)

Portmann, T., M. Yang, R. Mao, G. Panagiotakos, J. Ellegood, G. Dolen, P. L. Bader, B. A. Grueter, C. Goold, E. Fisher, K. Clifford, P. Rengarajan, D. Kalikhman, D. Loureiro, N. L. Saw, Z. Zhengqui, M. A. Miller, J. P. Lerch, R. M. Henkelman, M. Shamloo, R. C. Malenka, J. N. Crawley and R. E. Dolmetsch (2014). "Behavioral abnormalities and circuit defects in the basal ganglia of a mouse model of 16p11.2 deletion syndrome." Cell Rep 7(4): 1077-1092. (co-authored by Mouse Imaging Centre staff)

Rennie, M.Y., J. Mu, A. Rahman, D. Qu, K.J. Whiteley, J.G. Sled, and S.L. Adamson. (2014). “The Uteroplacental, Regoplacental, and Yolk Sac Circulations in the Mouse.” The Guide to Investigation of Mouse Pregnancy: 201. (co-authored by Mouse Imaging Centre staff)

Rennie, M.Y., K.J. Whiteley, J.G. Sled, and S.L. Adamson. (2014). “Scanning Electron Microscopy and Micro-Computed Tomography Imaging of the Utero- and Fetoplacental Circulations.” The Guide to Investigation of Mouse Pregnancy: 637. (co-authored by Mouse Imaging Centre staff)

Shynlova, O., A. Dorogin, Y. Li and S. Lye (2014). "Inhibition of infection-mediated preterm birth by administration of broad spectrum chemokine inhibitor in mice." J Cell Mol Med 18(9): 1816-1829.

Soares, F., I. Tattoli, M. A. Rahman, S. J. Robertson, A. Belcheva, D. Liu, C. Streutker, S. Winer, D. A. Winer, A. Martin, D. J. Philpott, D. Arnoult and S. E. Girardin (2014). "The mitochondrial protein NLRX1 controls the balance between extrinsic and intrinsic apoptosis." J Biol Chem 289(28): 19317-19330.

Sykes, E. A., Q. Dai, K. M. Tsoi, D. M. Hwang and W. C. Chan (2014). "Nanoparticle exposure in animals can be visualized in the skin and analysed via skin biopsy." Nat Commun 5: 3796.

Thomson, B. R., S. Heinen, M. Jeansson, A. K. Ghosh, A. Fatima, H. K. Sung, T. Onay, H. Chen, S. Yamaguchi, A. N. Economides, A. Flenniken, N. W. Gale, Y. K. Hong, A. Fawzi, X. Liu, T. Kume and S. E. Quaggin (2014). "A lymphatic defect causes ocular hypertension and glaucoma in mice." J Clin Invest 124(10): 4320-4324. (co-authored by TCP staff)

Tsui, A. K., P. A. Marsden, C. D. Mazer, J. G. Sled, K. M. Lee, R. M. Henkelman, L. S. Cahill, Y. Q. Zhou, N. Chan, E. Liu and G. M. Hare (2014). "Differential HIF and NOS responses to acute anemia: defining organ-specific hemoglobin thresholds for tissue hypoxia." Am J Physiol Regul Integr Comp Physiol 307(1): R13-25. . (co-authored by Mouse Imaging Centre staff)

Ussher, J. R., L. L. Baggio, J. E. Campbell, E. E. Mulvihill, M. Kim, M. G. Kabir, X. Cao, B. M. Baranek, D. A. Stoffers, R. J. Seeley and D. J. Drucker (2014). "Inactivation of the cardiomyocyte glucagon-like peptide-1 receptor (GLP-1R) unmasks cardiomyocyte-independent GLP-1R-mediated cardioprotection." Mol Metab 3(5): 507-517.

Van Doormaal, M., Y. Q. Zhou, X. Zhang, D. A. Steinman and R. Mark Henkelman (2014). "Inputs for subject-specific computational fluid dynamics simulation of blood flow in the mouse aorta." J Biomech Eng 136(10): 101008. . (co-authored by Mouse Imaging Centre staff)

Wong, M. D., Y. Maezawa, J. P. Lerch and R. M. Henkelman (2014). "Automated pipeline for anatomical phenotyping of mouse embryos using micro-CT." Development 141(12): 2533-2541. (co-authored by Mouse Imaging Centre staff)

Wu, A. M., M. Yang, P. Dalvi, A. L. Turinsky, W. Wang, D. Butcher, S. E. Egan, R. Weksberg, P. A. Harper and S. Ito (2014). "Role of STAT5 and epigenetics in lactation-associated upregulation of multidrug transporter ABCG2 in the mammary gland." Am J Physiol Endocrinol Metab 307(7): E596-610.

Zander, M. A., G. I. Cancino, T. Gridley, D. R. Kaplan and F. D. Miller (2014). "The Snail transcription factor regulates the numbers of neural precursor cells and newborn neurons throughout mammalian life." PLoS One 9(8): e104767.