International Mouse Phenotyping Consortium
Joint IMPC-Toronto (CMHD/TCP/MICe) & IMPC Phenotyping Workshop

THURSDAY 08 APRIL 2010 - IMPC-TORONTO SCIENTIFIC SESSION

Scientific Session (Day 1)
JJR Macleod Auditorium
University of Toronto, 1 King's College Circle

8:00 - 8:20am	Welcome to Meeting IMPC-Toronto (Colin McKerlie) & IMPC (Mark Moore)
	Session 1- Imaging for Phenotyping Chair: Mark Henkelman, The Hospital for Sick Children
8:20 - 9:00am	Joan Greve, Genentech The Importance of phenotyping in drug development: A convert's perspective
9:00 - 9:40am	Mark Henkelman, The Hospital for Sick Children 3D imaging of mouse brains and embryos
9:40 - 10:20am	Jason Lerch, The Hospital for Sick Children Automatic phenotyping from 3D images
10:20 - 10:50am	Health Break
10:50 - 12:00pm	Imaging for Phenotyping - Speaker Panel & Audience Discussion Chair: Mark Moore, IMPC

	Session 2 - Phenotyping Embryonic Lethality Chair: Janet Rossant, The Hospital for Sick Children
1:30 - 2:10pm	Janet Rossant, The Hospital for Sick Children How to make sense of embryonic lethal phenotypes
2:10 - 2:50pm	Chi-chung (C-c) Hui, The Hospital for Sick Children Analysis of embryonic phenotypes: Lessons from the dissection of the Hedgehog pathway
2:50 - 3:30pm	Cecilia Lo, University of Pittsburgh High throughput mouse phenotyping by noninvasive in utero echocardiography
3:30 - 4:00pm	Health Break
4:00 - 4:40pm	Mary Dickinson, Baylor College of Medicine 4D imaging of cardiovascular function in mouse embryos using optical coherence tomography
4:40 - 5:20pm	Phenotyping Embryonic Lethality - Speaker Panel & Audience Discussion Chair: Mark Moore, IMPC

FRIDAY 09 APRIL 2010 - IMPC PHENOTYPING RESOURCES SCIENTIFIC SESSION

Scientific Session (Day 2)
JJR Macleod Auditorium
University of Toronto, 1 King's College Circle

	Session 1 - Large-scale Resources for Discovery Phenotyping Chair: Mark Moore
8:00 - 8:30am	Mark Moore, IMPC Overview of the IMPC
8:30 - 9:00am	Bruce Beutler, The Scripps Research Institute Immunological phenotypes and the detection and archiving of incidental mutations
9:00 - 9:30am	Karen Svenson, The Jackson Laboratory Phenotyping at The Jackson Laboratory: Process and success of high-throughput strategies
9:30 - 10:00am	Cory Brayton, Johns Hopkins University JHU Phenotyping Collaborative Core: Concept & practice
10:00 - 10:30am	David Wasserman, Vanderbilt University Phenotyping mouse models of metabolic disease
10:30 - 11:00am	Health Break
11:00 - 11:30am	Rima Al-awar & Pradip Majumder, Ontario Institute for Cancer Research Phenotyping for new cancer drugs
11:30 - 12:00pm	Jane Aubin, University of Toronto Phenotyping for mouse models of human bone disease

	Session 2 - Industrial Approaches to Phenotyping Chair: Andy Peterson, Genentech
1:30 - 2:00pm	Andy Peterson, Genentech A mouse knockout resource for analysis of the biological functions of secreted and transmembrane proteins
2:00 - 2:30pm	Nick Gale, Regeneron Pharmaceuticals Using knockout mouse phenotyping and reporter expression analysis as a high-throughput target validation screen
2:30 - 3:00pm	Monical Justice, Baylor College of Medicine Assessing mouse phenotypes: The next steps
3:00 - 3:30pm	Health Break
3:30 - 4:00pm	Capacity, Outputs, and Data Types from Emerging Pipelines - Speaker Panel & Audience Discussion Chair: Steve Brown, MRC Harwell Mammalian Genetics Unit
4:00 - 4:15pm	Wrap-up & Conclusions Mark Moore, IMPC